Surgical resection for hilar cholangiocarcinoma

Strong R.W. and Lynch S.V. (1995) Surgical resection for hilar cholangiocarcinoma. Journal of Hepato-Biliary-Pancreatic Surgery, 2 3: 233-238. doi:10.1007/BF02350904

Author Strong R.W.
Lynch S.V.
Title Surgical resection for hilar cholangiocarcinoma
Journal name Journal of Hepato-Biliary-Pancreatic Surgery   Check publisher's open access policy
ISSN 0944-1166
Publication date 1995-01-01
Sub-type Article (original research)
DOI 10.1007/BF02350904
Open Access Status
Volume 2
Issue 3
Start page 233
End page 238
Total pages 6
Publisher Springer-Verlag
Subject 2746 Surgery
Abstract A retrospective analysis of 62 patients who underwent resection for hilar cholangiocarcinoma performed between 1981-1994 was undertaken. Type I lesions and patients whose operations were performed less than 24 months prior to analysis were excluded, leaving a study cohort of 48 patients (27 male: 21 female, median age 66 years, range 23-86 years). Median post-operative stay was 20 days (8-60) with peri-operative mortality of 10.4%. Histopathological grading of paraffin sections of excised tumours was made, using standard criteria, into poor, moderate, and well differentiated lesions, and the three sub-groups were separately analysed. Patients with poorly differentiated lesions (n=16) had a median survival of 7 months (range 0-24), with 1-and 2-year survival of 19% and 0%, respectively. The median survival of patients with moderately differentiated tumours (n=20) was 27 months (range 0-84), with 1-, 2-, 3-, and 5-year survival of 70%, 55%, 35%, and 22%, respectively. Those with well differentiated carcinomas (n=12) fared better, with a median survival of 62 months (range 16-120) and 1-, 2-, 3-, and 5-year survival of 100%, 66%, 66%, and 58%, respectively. Differences in survival were highly significant at P<0.0001. Patients with poorly differentiated tumours would be best served by non-surgical intervention if this differentiation could be reliably made pre-operatively. Conversely, those with more favourable histological grading are potentially curable by an aggressive radical resection.
Keyword high bile duct cancer
hilar cholangiocarcinoma
Q-Index Code C1
Q-Index Status Provisional Code
Institutional Status Unknown

Document type: Journal Article
Sub-type: Article (original research)
Collection: Scopus Import - Archived
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Created: Tue, 05 Jul 2016, 11:19:36 EST by System User