Lung gas mixing during expiration following an inspiration of air

Davidson M.R. (1975) Lung gas mixing during expiration following an inspiration of air. Bulletin of Mathematical Biology, 37 2: 113-126. doi:10.1007/BF02470618

Author Davidson M.R.
Title Lung gas mixing during expiration following an inspiration of air
Journal name Bulletin of Mathematical Biology   Check publisher's open access policy
ISSN 0007-4985
Publication date 1975-01-01
Sub-type Article (original research)
DOI 10.1007/BF02470618
Volume 37
Issue 2
Start page 113
End page 126
Total pages 14
Publisher Kluwer Academic Publishers
Language eng
Subject 1100 Agricultural and Biological Sciences
Abstract The airway system of the lung from the mouth to the pulmonary membrane is modelled by matching a cylindrical model of a pathway through the respiratory region of the lung onto a one-dimensional trumpet model for the conducting airways. The concentration of O2 in gas expired from this model airway system is investigated following an inspiration of air at two different flow rates (10 litres/min and 85 litres/min). In each case, expiration occurs at the same constant flow rate as that during the previous inspiration. The inspirations, which are studied in an earlier paper, are each of 2 sec duration and begin at a lung volume of 2300 ml and a lung oxygen tension of 98 mm Hg. The equations are solved numerically and plots of expired O2 concentration against time and against expired volume are shown. It is found that at 85 litres/min, gas mixing in the lung is complete after about 0.7 sec of expiration whereas at 10 litres/min, about 2.6 sec of expiration is required for complete equilibration. It is suggested that the experimental alveolar plateau slope is not in general caused by a slow approach to equilibrium of gas concentrations; except at very low flow rates in the early part of the concentration/time plateau.
Q-Index Code C1
Q-Index Status Provisional Code
Institutional Status Unknown

Document type: Journal Article
Sub-type: Article (original research)
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Citation counts: TR Web of Science Citation Count  Cited 12 times in Thomson Reuters Web of Science Article | Citations
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