Peripheral progesterone concentrations in the luteal-phase ewe: Effects of a β-adrenergic receptor antagonist and two β2-adrenergic agonists

Wheeler A.G., Lean J. and Walker M. (1988) Peripheral progesterone concentrations in the luteal-phase ewe: Effects of a β-adrenergic receptor antagonist and two β2-adrenergic agonists. Journal of Endocrinology, 116 1: 137-142.

Author Wheeler A.G.
Lean J.
Walker M.
Title Peripheral progesterone concentrations in the luteal-phase ewe: Effects of a β-adrenergic receptor antagonist and two β2-adrenergic agonists
Journal name Journal of Endocrinology   Check publisher's open access policy
ISSN 0022-0795
Publication date 1988-01-01
Sub-type Article (original research)
Open Access Status Not yet assessed
Volume 116
Issue 1
Start page 137
End page 142
Total pages 6
Language eng
Subject 1310 Endocrinology
Abstract Peripheral blood samples were collected at 10-min intervals from three conscious sheep in which ovulation had been induced 6-10 days previously using exogenous hormones. Saline was infused into a jugular vein for about 1 h, followed by the experimental drug for 1-2 h and followed by saline again for a further 2 h. The experiments were repearted following induced luteolysis and ovulation. The infusion of a β-adrenergic antagonist (propranolol) into three conscious luteal-phase ewes decreased (P < 0·05) the peripheral progesterone concentration in each animal. Infusions of β-adrenergic agonists (ritodrine and salbutamol) increased (P < 0·05) the progesterone concentration in four out of eight experiments. The β-adrenergic antagonists decreased the heart rate and the β-adrenergic agonist increased it; the arterial blood pressure and respiratory rate were unaffected. The decrease in the progesterone concentration in response to the β-adrenergic antagonist suggests that the normal ovarian secretion of progesterone is partly the result of sympathetic stimulation, and that the sympathetic innervation of the ovary may have a physiological role in modulating progesterone secretion.
Q-Index Code C1
Q-Index Status Provisional Code
Institutional Status Unknown

Document type: Journal Article
Sub-type: Article (original research)
Collection: Scopus Import - Archived
 
Versions
Version Filter Type
Citation counts: Scopus Citation Count Cited 16 times in Scopus Article | Citations
Google Scholar Search Google Scholar
Created: Tue, 05 Jul 2016, 10:58:54 EST by System User