The amygdaloid complex: Anatomy and physiology

Sah, P, Faber, ESL, De Armentia, ML and Power, J (2003) The amygdaloid complex: Anatomy and physiology. Physiological Reviews, 83 3: 803-834. doi:10.1152/physrev.00002.2003

Author Sah, P
Faber, ESL
De Armentia, ML
Power, J
Title The amygdaloid complex: Anatomy and physiology
Journal name Physiological Reviews   Check publisher's open access policy
ISSN 0031-9333
Publication date 2003-01-01
Year available 2003
Sub-type Critical review of research, literature review, critical commentary
DOI 10.1152/physrev.00002.2003
Open Access Status DOI
Volume 83
Issue 3
Start page 803
End page 834
Total pages 32
Place of publication Bethesda
Publisher Amer Physiological Soc
Language eng
Subject 110902 Cellular Nervous System
Abstract A converging body of literature over the last 50 years has implicated the amygdala in assigning emotional significance or value to sensory information. In particular, the amygdala has been shown to be an essential component of the circuitry underlying fear-related responses. Disorders in the processing of fear-related information are likely to be the underlying cause of some anxiety disorders in humans such as posttraumatic stress. The amygdaloid complex is a group of more than 10 nuclei that are located in the midtemporal lobe. These nuclei can be distinguished both on cytoarchitectonic and connectional grounds. Anatomical tract tracing studies have shown that these nuclei have extensive intranuclear and internuclear connections. The afferent and efferent connections of the amygdala have also been mapped in detail, showing that the amygdaloid complex has extensive connections with cortical and subcortical regions. Analysis of fear conditioning in rats has suggested that long-term synaptic plasticity of inputs to the amygdala underlies the acquisition and perhaps storage of the fear memory. In agreement with this proposal, synaptic plasticity has been demonstrated at synapses in the amygdala in both in vitro and in vivo studies. In this review, we examine the anatomical and physiological substrates proposed to underlie amygdala function.
Keyword Physiology
Long-term Potentiation
Rat Basolateral Amygdala
Metabotropic Glutamate Receptors
Conditioned Taste-aversion
Central Nucleus Lesions
Medial Geniculate-body
Midbrain Periaqueductal Gray
Gaba-like Immunoreactivity
Q-Index Code C1
Q-Index Status Provisional Code
Institutional Status Unknown
Additional Notes This document is a journal review.

Document type: Journal Article
Sub-type: Critical review of research, literature review, critical commentary
Collections: Excellence in Research Australia (ERA) - Collection
Queensland Brain Institute Publications
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Citation counts: TR Web of Science Citation Count  Cited 782 times in Thomson Reuters Web of Science Article | Citations
Scopus Citation Count Cited 823 times in Scopus Article | Citations
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Created: Mon, 13 Aug 2007, 23:38:53 EST