Obesity and cardiovascular disease

Ortega, Francisco B., Lavie, Carl J. and Blair, Steven N. (2016) Obesity and cardiovascular disease. Circulation Research, 118 11: 1752-1770. doi:10.1161/CIRCRESAHA.115.306883

Author Ortega, Francisco B.
Lavie, Carl J.
Blair, Steven N.
Title Obesity and cardiovascular disease
Journal name Circulation Research   Check publisher's open access policy
ISSN 0009-7330
Publication date 2016-05-27
Year available 2016
Sub-type Article (original research)
DOI 10.1161/CIRCRESAHA.115.306883
Open Access Status Not yet assessed
Volume 118
Issue 11
Start page 1752
End page 1770
Total pages 19
Place of publication Philadelphia, PA United States
Publisher Lippincott Williams & Wilkins
Language eng
Abstract The prevalence of obesity has increased worldwide over the past few decades. In 2013, the prevalence of obesity exceeded the 50% of the adult population in some countries from Oceania, North Africa, and Middle East. Lower but still alarmingly high prevalence was observed in North America (≈30%) and in Western Europe (≈20%). These figures are of serious concern because of the strong link between obesity and disease. In the present review, we summarize the current evidence on the relationship of obesity with cardiovascular disease (CVD), discussing how both the degree and the duration of obesity affect CVD. Although in the general population, obesity and, especially, severe obesity are consistently and strongly related with higher risk of CVD incidence and mortality, the one-size-fits-all approach should not be used with obesity. There are relevant factors largely affecting the CVD prognosis of obese individuals. In this context, we thoroughly discuss important concepts such as the fat-but-fit paradigm, the metabolically healthy but obese (MHO) phenotype and the obesity paradox in patients with CVD. About the MHO phenotype and its CVD prognosis, available data have provided mixed findings, what could be partially because of the adjustment or not for key confounders such as cardiorespiratory fitness, and to the lack of consensus on the MHO definition. In the present review, we propose a scientifically based harmonized definition of MHO, which will hopefully contribute to more comparable data in the future and a better understanding on the MHO subgroup and its CVD prognosis.
Keyword Cardiovascular diseases
Metabolically healthy obesity
Q-Index Code C1
Q-Index Status Provisional Code
Institutional Status UQ

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Sub-type: Article (original research)
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