STroke imAging pRevention and treatment (START): A longitudinal stroke cohort study: Clinical trials protocol

Carey, Leeanne M., Crewther, Sheila, Salvado, Olivier, Linden, Thomas, Connelly, Alan, Wilson, William, Howells, David W., Churilov, Leonid, Ma, Henry, Tse, Tamara, Rose, Stephen, Palmer, Susan, Bougeat, Pierrick, Campbell, Bruce C. V., Christensen, Soren, Macaulay, S. Lance, Favaloro, Jenny, O' Collins, Victoria, McBride, Simon, Bates, Susan, Cowley, Elise, Dewey, Helen, Wijeratne, Tissa, Gerraty, Richard, Phan, Thanh G., Yan, Bernard, Parsons, Mark W., Bladin, Chris, Barber, P. Alan, Read, Stephen, Wong, Andrew, Lee, Andrew, Kleinig, Tim, Hankey, Graeme J., Blacker, David, Markus, Romesh, Leyden, James, Krause, Martin, Grimley, Rohan, Mahant, Neil, Jannes, Jim, Sturm, Jonathan, Davis, Stephen M. and Donnan, Geoffrey A. (2015) STroke imAging pRevention and treatment (START): A longitudinal stroke cohort study: Clinical trials protocol. International Journal of Stroke, 10 4: 636-644. doi:10.1111/ijs.12190

Author Carey, Leeanne M.
Crewther, Sheila
Salvado, Olivier
Linden, Thomas
Connelly, Alan
Wilson, William
Howells, David W.
Churilov, Leonid
Ma, Henry
Tse, Tamara
Rose, Stephen
Palmer, Susan
Bougeat, Pierrick
Campbell, Bruce C. V.
Christensen, Soren
Macaulay, S. Lance
Favaloro, Jenny
O' Collins, Victoria
McBride, Simon
Bates, Susan
Cowley, Elise
Dewey, Helen
Wijeratne, Tissa
Gerraty, Richard
Phan, Thanh G.
Yan, Bernard
Parsons, Mark W.
Bladin, Chris
Barber, P. Alan
Read, Stephen
Wong, Andrew
Lee, Andrew
Kleinig, Tim
Hankey, Graeme J.
Blacker, David
Markus, Romesh
Leyden, James
Krause, Martin
Grimley, Rohan
Mahant, Neil
Jannes, Jim
Sturm, Jonathan
Davis, Stephen M.
Donnan, Geoffrey A.
Title STroke imAging pRevention and treatment (START): A longitudinal stroke cohort study: Clinical trials protocol
Journal name International Journal of Stroke   Check publisher's open access policy
ISSN 1747-4949
Publication date 2015-06-01
Year available 2015
Sub-type Article (original research)
DOI 10.1111/ijs.12190
Open Access Status Not Open Access
Volume 10
Issue 4
Start page 636
End page 644
Total pages 9
Place of publication London, United Kingdom
Publisher Sage Publications
Language eng
Formatted abstract
Stroke and poststroke depression are common and have a profound and ongoing impact on an individual's quality of life. However, reliable biological correlates of poststroke depression and functional outcome have not been well established in humans.

Our aim is to identify biological factors, molecular and imaging, associated with poststroke depression and recovery that may be used to guide more targeted interventions.

In a longitudinal cohort study of 200 stroke survivors, the START – STroke imAging pRevention and Treatment cohort, we will examine the relationship between gene expression, regulator proteins, depression, and functional outcome. Stroke survivors will be investigated at baseline, 24 h, three-days, three-months, and 12 months poststroke for blood-based biological associates and at days 3–7, three-months, and 12 months for depression and functional outcomes. A sub-group (n = 100), the PrePARE: Prediction and Prevention to Achieve optimal Recovery Endpoints after stroke cohort, will also be investigated for functional and structural changes in putative depression-related brain networks and for additional cognition and activity participation outcomes. Stroke severity, diet, and lifestyle factors that may influence depression will be monitored. The impact of depression on stroke outcomes and participation in previous life activities will be quantified.

Study Outcomes

Clinical significance lies in the identification of biological factors associated with functional outcome to guide prevention and inform personalized and targeted treatments. Evidence of associations between depression, gene expression and regulator proteins, functional and structural brain changes, lifestyle and functional outcome will provide new insights for mechanism-based models of poststroke depression.
Keyword Cohort
Cortical thickness
Functional neuroimaging
Gene expression
Q-Index Code C1
Q-Index Status Provisional Code
Institutional Status Non-UQ

Document type: Journal Article
Sub-type: Article (original research)
Collection: UQ Centre for Clinical Research Publications
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