Pharmacokinetics and pharmacodynamics of oxycodone when given intravenously and rectally to adult patients with cancer pain

Leow, KP, Cramond, T and Smith, MT (1995) Pharmacokinetics and pharmacodynamics of oxycodone when given intravenously and rectally to adult patients with cancer pain. Anesthesia and Analgesia, 80 2: 296-302. doi:10.1097/00000539-199502000-00016


Author Leow, KP
Cramond, T
Smith, MT
Title Pharmacokinetics and pharmacodynamics of oxycodone when given intravenously and rectally to adult patients with cancer pain
Journal name Anesthesia and Analgesia   Check publisher's open access policy
ISSN 0003-2999
Publication date 1995-01-01
Year available 1995
Sub-type Article (original research)
DOI 10.1097/00000539-199502000-00016
Open Access Status Not yet assessed
Volume 80
Issue 2
Start page 296
End page 302
Total pages 7
Place of publication BALTIMORE
Publisher WILLIAMS & WILKINS
Language eng
Subject 2703 Anesthesiology and Pain Medicine
Abstract The single-dose pharmacokinetics and pharmacodynamics of oxycodone administered by the intravenous and rectal routes were determined in 12 adult cancer patients with moderate to severe cancer pain (visual analog scale [VAS] score, approximately 5). Oxycodone was administered by the intravenous and rectal routes with open drug administration and a cross-over design. After single-dose intravenous administration (7.9 +/- 1.5 mg, mean +/- SD), the mean (+/- SD) terminal half-life was 3.4 h (+/- 1.1), the mean (+/- SD) plasma clearance was 45.4 L/h (+/- 10.1), and the mean (+/- SD) volume of distribution in the terminal phase was 3.0 L/kg (+/- 1.1). After rectal oxycodone (30 mg), the mean (+/- SD) absorption lag time was 0.52 h (+/- 0.29) and the mean (+/- SD) absolute bioavailability was 61.6% (+/- 30.2%). Intravenous oxycodone was associated with a rapid onset of pain relief (5-8 min) in contrast to the 0.5- to 1.0-h delay observed after rectal administration. However, rectal oxycodone provided analgesia of much longer duration (approximate to 8-12 h) than did inhavenous oxycodone (approximate to 4 h). There were no significant differences (P > 0.05) in the incidence and severity of side effects between inhavenous and rectal oxycodone. The marked interindividual variation observed in the pharmacokinetics and pharmacodynamics of oxycodone in this study emphasizes the need for individualized dosing regimens.
Keyword Anesthesiology
Anesthesiology
ANESTHESIOLOGY
Q-Index Code C1
Q-Index Status Provisional Code
Institutional Status Unknown

Document type: Journal Article
Sub-type: Article (original research)
Collection: ResearcherID Downloads - Archived
 
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