The unsteady model - An alternative approach to nonlinear pharmacokinetics

Smith M.T. and Smith T.C. (1981) The unsteady model - An alternative approach to nonlinear pharmacokinetics. European Journal of Clinical Pharmacology, 20 5: 387-398. doi:10.1007/BF00615410


Author Smith M.T.
Smith T.C.
Title The unsteady model - An alternative approach to nonlinear pharmacokinetics
Journal name European Journal of Clinical Pharmacology   Check publisher's open access policy
ISSN 0031-6970
Publication date 1981-01-01
Year available 1981
Sub-type Article (original research)
DOI 10.1007/BF00615410
Open Access Status Not yet assessed
Volume 20
Issue 5
Start page 387
End page 398
Total pages 12
Place of publication NEW YORK
Publisher Springer-Verlag
Language eng
Subject 3000 Pharmacology, Toxicology and Pharmaceutics
2736 Pharmacology (medical)
Abstract In this paper an alternative approach to nonlinear pharmacokinetic modelling has been developed from first principles. This "Unsteady Model" is able to describe the situation whereby one or more independent drugs and their metabolites compete for free attachment sites in liver, tissue, red blood cells etc. The Unsteady model collapses to well-known existing models viz.: Michaelis-Menten, Langmuir tissue binding and the linear compartment models, under certain well-defined, limiting conditions. The Unsteady model and its collapse to existing models is derived mathematically and illustrated with simulations. For several reasons the Unsteady model would appear to have many advantages and wide application.
Keyword nonlinear
pharmacokinetic model
simulation
unsteady model
Q-Index Code C1
Q-Index Status Provisional Code
Institutional Status Unknown

Document type: Journal Article
Sub-type: Article (original research)
Collection: Scopus Import - Archived
 
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Created: Sat, 02 Jul 2016, 02:10:37 EST by Ms Kate Rowe