Metabolism of propranolol in the human maternal-placental-foetal unit

Smith, MT, Livingstone, I, Eadie, MJ, Hooper, WD and Triggs, EJ (1983) Metabolism of propranolol in the human maternal-placental-foetal unit. European Journal of Clinical Pharmacology, 24 6: 727-732. doi:10.1007/BF00607078


Author Smith, MT
Livingstone, I
Eadie, MJ
Hooper, WD
Triggs, EJ
Title Metabolism of propranolol in the human maternal-placental-foetal unit
Journal name European Journal of Clinical Pharmacology   Check publisher's open access policy
ISSN 0031-6970
Publication date 1983-01-01
Sub-type Article (original research)
DOI 10.1007/BF00607078
Volume 24
Issue 6
Start page 727
End page 732
Total pages 6
Publisher Springer-Verlag
Language eng
Subject 3000 Pharmacology, Toxicology and Pharmaceutics
2736 Pharmacology (medical)
Abstract Propranolol (P) and all of its major known metabolites were found in maternal plasma, cord plasma and neonatal plasma in 10 women at term, irrespective of the P doses administered and the time elapsed (up to 15 h) between administration of the last P dose and delivery. The ratios of cord plasma to simultaneous maternal plasma levels for propranolol and its major metabolites (mean±SD) were: propranolol 0.32±0.17, propranolol glucuronide 0.86±0.36, 4-hydroxypropranolol 1.4±1.0, 4-hydroxypropranolol glucuronide 0.71±0.45 and naphthoxylactic acid 3.0±1.6. P binding in cord plasma at delivery was 67.2±3.9% (mean±SD) which was significantly less ('t'=13.4, df=13, p<0.001) than the P binding in maternal plasma at delivery (87.5±1.6%, mean±SD). The plasma protein binding (mean±SD) of naphthoxylactic acid in cord plasma (98.6±0.2%) was significantly greater ('t'=3.808, df=4, p<0.02) than the naphthoxylactic acid binding in maternal plasma at delivery (97.6±0.4%). When the simultaneous concentrations of P and naphthoxylactic acid in maternal and cord plasma are compared in conjunction with protein binding and ionic effects, it would seem that metabolism of P does occur in the placental/foetal unit.
Keyword delivery
foetus
metabolism
placenta
plasma levels
plasma protein binding
pregnancy
propranolol
Q-Index Code C1
Q-Index Status Provisional Code
Institutional Status Unknown

Document type: Journal Article
Sub-type: Article (original research)
Collection: Scopus Import
 
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Created: Sat, 02 Jul 2016, 01:52:26 EST by Ms Kate Rowe