Bioavailability and pharmacokinetics of phenytoin during pregnancy

Lander C.M., Smith M.T., Chalk J.B., de Wytt C., Symoniw P., Livingstone I. and Eadie M.J. (1984) Bioavailability and pharmacokinetics of phenytoin during pregnancy. European Journal of Clinical Pharmacology, 27 1: 105-110. doi:10.1007/BF00553163


Author Lander C.M.
Smith M.T.
Chalk J.B.
de Wytt C.
Symoniw P.
Livingstone I.
Eadie M.J.
Title Bioavailability and pharmacokinetics of phenytoin during pregnancy
Journal name European Journal of Clinical Pharmacology   Check publisher's open access policy
ISSN 0031-6970
Publication date 1984-01-01
Sub-type Article (original research)
DOI 10.1007/BF00553163
Volume 27
Issue 1
Start page 105
End page 110
Total pages 6
Publisher Springer-Verlag
Subject 3000 Pharmacology, Toxicology and Pharmaceutics
2736 Pharmacology (medical)
Abstract Five epileptic women needing to commence phenytoin therapy during pregnancy received a single intravenous and a single oral dose of phenytoin several days apart before starting regular intake of the drug. Plasma phenytoin concentration - time data were analysed by three different pharmacokinetic techniques. However assessed, the mean oral bioavailability of the drug proved to be about 90% of the intravenous bioavailability. This finding makes it unlikely that impaired bioavailability accounts for the increase in oral phenytoin dosage necessary in pregnancy to maintain plasma phenytoin concentrations at pre-pregnancy values. Phenytoin clearance in the pregnant subjects was approximately double the published values for phenytoin clearance in nonpregnant persons. This suggests that increased (metabolic) clearance accounts for the increased phenytoin dosage requirement of pregnancy.
Keyword bioavailability
epileptic women
pharmacokinetics
phenytoin
pregnancy
Q-Index Code C1
Q-Index Status Provisional Code
Institutional Status Unknown

Document type: Journal Article
Sub-type: Article (original research)
Collection: Scopus Import - Archived
 
Versions
Version Filter Type
Citation counts: Scopus Citation Count Cited 30 times in Scopus Article | Citations
Google Scholar Search Google Scholar
Created: Sat, 02 Jul 2016, 01:48:38 EST by Ms Kate Rowe