Morphine-3-glucuronide - a potent antagonist of morphine analgesia

Smith M.T., Watt J.A. and Cramond T. (1990) Morphine-3-glucuronide - a potent antagonist of morphine analgesia. Life Sciences, 47 6: 579-585. doi:10.1016/0024-3205(90)90619-3

Author Smith M.T.
Watt J.A.
Cramond T.
Title Morphine-3-glucuronide - a potent antagonist of morphine analgesia
Journal name Life Sciences   Check publisher's open access policy
ISSN 0024-3205
Publication date 1990-01-01
Year available 1990
Sub-type Article (original research)
DOI 10.1016/0024-3205(90)90619-3
Open Access Status Not yet assessed
Volume 47
Issue 6
Start page 579
End page 585
Total pages 7
Place of publication OXFORD
Language eng
Subject 3004 Pharmacology
Abstract In this study, morphine-3-glucuronide (M3G), the major plasma and urinary metabolite of morphine, was shown to be a potent antagonist of morphine analgesia when administered to rats by the intra-cerebroventricular (i.c.v.) route. The antagonism of morphine analgesia was observed irrespective of whether i.c.v. M3G (2.5 or 3.0μg) was administered 15 mins prior to or 15 mins after i.c.v. morphine (20μg). When M3G (10mg) was administered intraperitoneally (i.p.) to rats 30-40 mins prior to morphine (1.5mg i.p.), the analgesic response was significantly reduced compared to administration of morphine (1.5mg i.p.) alone. It was further demonstrated that i.c.v. M3G (2.0μg) antagonized the analgesic effects of subsequently administered i.c.v. morphine-6-glucuronide (0.25μg).
Keyword Medicine, Research & Experimental
Pharmacology & Pharmacy
Research & Experimental Medicine
Pharmacology & Pharmacy
Q-Index Code C1
Q-Index Status Provisional Code
Institutional Status Unknown

Document type: Journal Article
Sub-type: Article (original research)
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