Dose-dependent pharmacokinetics of caffeine in humans: Relevance as a test of quantitative liver function

Cheng W.S.C., Murphy T.L., Smith M.T., Cooksley W.G.E., Halliday J.W. and Powell L.W. (1990) Dose-dependent pharmacokinetics of caffeine in humans: Relevance as a test of quantitative liver function. Clinical Pharmacology and Therapeutics, 47 4: 516-524. doi:10.1038/clpt.1990.66


Author Cheng W.S.C.
Murphy T.L.
Smith M.T.
Cooksley W.G.E.
Halliday J.W.
Powell L.W.
Title Dose-dependent pharmacokinetics of caffeine in humans: Relevance as a test of quantitative liver function
Journal name Clinical Pharmacology and Therapeutics   Check publisher's open access policy
ISSN 0009-9236
Publication date 1990-01-01
Year available 1990
Sub-type Article (original research)
DOI 10.1038/clpt.1990.66
Open Access Status Not yet assessed
Volume 47
Issue 4
Start page 516
End page 524
Total pages 9
Place of publication ST LOUIS
Publisher MOSBY-YEAR BOOK INC
Language eng
Subject 3004 Pharmacology
Abstract Caffeine clearance was determined in 13 healthy control subjects and in 13 patients with histologically proven cirrhosis. On separate occasions, 70 mg, 200 mg, and 300 mg single doses of anhydrous caffeine were administered orally with decaffeinated coffee to each subject. Subjects were analyzed individually, acting as their own controls, thus reducing interindividual variability. The present study showed that caffeine exhibited dose-dependent pharmacokinetics, particularly in subjects who showed high initial clearance with the low dose (70 mg) of caffeine. There was a significant decrease in caffeine clearance with increasing dose from 70 mg to 300 mg (n = 26, p < 0.01, Dunnett's test), indicating saturable caffeine metabolism in the dose range tested. These findings imply that if caffeine is to be used as a guide to deteriorating liver function, serial caffeine clearance estimations should be performed in each individual subject, with use of the same dose of caffeine each time.
Q-Index Code C1
Q-Index Status Provisional Code
Institutional Status Unknown

Document type: Journal Article
Sub-type: Article (original research)
Collection: Scopus Import - Archived
 
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Created: Sat, 02 Jul 2016, 01:33:56 EST by Ms Kate Rowe