Nuclear factor one B (NFIB) encodes a subtype-specific tumour suppressor in glioblastoma

Stringer, Brett W., Bunt, Jens, Day, Bryan W., Barry, Guy, Jamieson, Paul R., Ensbey, Kathleen S., Bruce, Zara C., Goasdoué, Kate, Vidal, Helene, Charmsaz, Sara, Smith, Fiona M., Cooper, Leanne T., Piper, Michael, Boyd, Andrew W. and Richards, Linda J. (2016) Nuclear factor one B (NFIB) encodes a subtype-specific tumour suppressor in glioblastoma. Oncotarget, 7 20: 29306-12320. doi:10.18632/oncotarget.8720

Author Stringer, Brett W.
Bunt, Jens
Day, Bryan W.
Barry, Guy
Jamieson, Paul R.
Ensbey, Kathleen S.
Bruce, Zara C.
Goasdoué, Kate
Vidal, Helene
Charmsaz, Sara
Smith, Fiona M.
Cooper, Leanne T.
Piper, Michael
Boyd, Andrew W.
Richards, Linda J.
Title Nuclear factor one B (NFIB) encodes a subtype-specific tumour suppressor in glioblastoma
Journal name Oncotarget   Check publisher's open access policy
ISSN 1949-2553
Publication date 2016-04-13
Year available 2016
Sub-type Article (original research)
DOI 10.18632/oncotarget.8720
Open Access Status DOI
Volume 7
Issue 20
Start page 29306
End page 12320
Total pages 15
Place of publication Albany, NY United States
Publisher Impact Journals
Language eng
Subject 2730 Oncology
Abstract Glioblastoma (GBM) is an essentially incurable and rapidly fatal cancer, with few markers predicting a favourable prognosis. Here we report that the transcription factor NFIB is associated with significantly improved survival in GBM. NFIB expression correlates inversely with astrocytoma grade and is lowest in mesenchymal GBM. Ectopic expression of NFIB in low-passage, patient-derived classical and mesenchymal subtype GBM cells inhibits tumourigenesis. Ectopic NFIB expression activated phospho-STAT3 signalling only in classical and mesenchymal GBM cells, suggesting a mechanism through which NFIB may exert its context-dependent tumour suppressor activity. Finally, NFIB expression can be induced in GBM cells by drug treatment with beneficial effects.
Keyword Glioblastoma (GBM)
Nuclear factor I B (NFIB)
Tumour suppressor gene
GBM subtype
Q-Index Code C1
Q-Index Status Provisional Code
Grant ID 1010857
Institutional Status UQ

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Created: Thu, 30 Jun 2016, 21:10:29 EST by Jens Bunt on behalf of Queensland Brain Institute