Genome-centric resolution of microbial diversity, metabolism and interactions in anaerobic digestion

Vanwonterghem, Inka, Jensen, Paul D., Rabaey, Korneel and Tyson, Gene W. (2016) Genome-centric resolution of microbial diversity, metabolism and interactions in anaerobic digestion. Environmental Microbiology, 18 9: 3144-3158. doi:10.1111/1462-2920.13382

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Author Vanwonterghem, Inka
Jensen, Paul D.
Rabaey, Korneel
Tyson, Gene W.
Title Genome-centric resolution of microbial diversity, metabolism and interactions in anaerobic digestion
Journal name Environmental Microbiology   Check publisher's open access policy
ISSN 1462-2920
1462-2912
Publication date 2016-09-01
Year available 2016
Sub-type Article (original research)
DOI 10.1111/1462-2920.13382
Open Access Status Not Open Access
Volume 18
Issue 9
Start page 3144
End page 3158
Total pages 15
Place of publication Chichester, West Sussex United Kingdom
Publisher Wiley-Blackwell Publishing
Language eng
Subject 2404 Microbiology
1105 Ecology, Evolution, Behavior and Systematics
Abstract Our understanding of the complex interconnected processes performed by microbial communities is hindered by our inability to culture the vast majority of microorganisms. Metagenomics provides a way to bypass this cultivation bottleneck and recent advances in this field now allow us to recover a growing number of genomes representing previously uncultured populations from increasingly complex environments. In this study, a temporal genome-centric metagenomic analysis was performed of lab-scale anaerobic digesters that host complex microbial communities fulfilling a series of interlinked metabolic processes to enable the conversion of cellulose to methane. In total, 101 population genomes that were moderate to near-complete were recovered based primarily on differential coverage binning. These populations span 19 phyla, represent mostly novel species and expand the genomic coverage of several rare phyla. Classification into functional guilds based on their metabolic potential revealed metabolic networks with a high level of functional redundancy as well as niche specialization, and allowed us to identify potential roles such as hydrolytic specialists for several rare, uncultured populations. Genome-centric analyses of complex microbial communities across diverse environments provide the key to understanding the phylogenetic and metabolic diversity of these interactive communities.
Keyword Metagenomics
Genome-centric
Functional redundancy
Metabolic network
Anaerobic digestion
Novel diversity
Q-Index Code C1
Q-Index Status Provisional Code
Grant ID 2013/4008
DP1093175
Institutional Status UQ

Document type: Journal Article
Sub-type: Article (original research)
Collections: HERDC Pre-Audit
School of Chemistry and Molecular Biosciences
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Citation counts: TR Web of Science Citation Count  Cited 17 times in Thomson Reuters Web of Science Article | Citations
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Created: Tue, 28 Jun 2016, 22:20:46 EST by Mrs Louise Nimwegen on behalf of School of Chemistry & Molecular Biosciences