Non-Prescription Sympathomimetic Agents and Hypertension

Chua S.S. and Benrimoj S.I. (1988) Non-Prescription Sympathomimetic Agents and Hypertension. Medical Toxicology and Adverse Drug Experience, 3 5: 387-417. doi:10.1007/BF03259892

Author Chua S.S.
Benrimoj S.I.
Title Non-Prescription Sympathomimetic Agents and Hypertension
Journal name Medical Toxicology and Adverse Drug Experience   Check publisher's open access policy
ISSN 1179-1942
Publication date 1988-01-01
Sub-type Critical review of research, literature review, critical commentary
DOI 10.1007/BF03259892
Volume 3
Issue 5
Start page 387
End page 417
Total pages 31
Subject 3005 Toxicology
Abstract In recent years, considerable attention has been focused on the pressor effects of non-prescription sympathomimetic agents. The impact and usage of these agents especially ephedrine, pseudoephedrine, phenylpropanolamine and phenylephrine, in hypertensive patients has been the topic of constant debates. The present review is an attempt to report and evaluate all the clinical trials and cases of pressor reactions associated with these 4 agents. The study protocols used in these clinical trials are examined and comments made on any diversion from the standard design. Many factors are found to cause the discrepancies in the data available. It is concluded that ephedrine and phenylpropanolamine are best avoided by hypertensive patients due to higher probability of causing pressor reactions. Data on pseudoephedrine and phenylephrine appear to indicate non-significant effects on blood pressure of normotensive subjects when used at the recommended oral dose as nasal decongestants. Phenylephrine is also commonly employed in nasal and eye drops and the limited data available appear to support its usage in hypertensive patients. However, it is noted that most of the clinical trials involve normotensive subjects and the majority of the results could not be verified due to inadequacies in the study design. This paucity and inconclusive information on hypertensive patients warrants further investigations with emphasis on the study protocols used.
Q-Index Code C1
Q-Index Status Provisional Code
Institutional Status Unknown

Document type: Journal Article
Sub-type: Critical review of research, literature review, critical commentary
Collection: Scopus Import - Archived
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Citation counts: Scopus Citation Count Cited 23 times in Scopus Article | Citations
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