Anti-ganglioside antibodies in peripheral neuropathy.

McCombe P.A., Wilson R. and Prentice R.L. (1992) Anti-ganglioside antibodies in peripheral neuropathy.. Clinical and experimental neurology, 29 182-188.

Author McCombe P.A.
Wilson R.
Prentice R.L.
Title Anti-ganglioside antibodies in peripheral neuropathy.
Journal name Clinical and experimental neurology   Check publisher's open access policy
ISSN 0196-6383
Publication date 1992-01-01
Sub-type Article (original research)
Open Access Status Not yet assessed
Volume 29
Start page 182
End page 188
Total pages 7
Language eng
Subject 2700 Medicine
Abstract There have recently been reports that patients with motor neuropathy with multifocal conduction block have high circulating levels of antibodies to the ganglioside GM1. Other reports have described the presence of these antibodies in patients with inflammatory demyelinating neuropathy and patients with lower motor neurone forms of motor neurone disease. We have established an ELISA assay for IgG and IgM antibodies to asialo-GM1 (Sigma). We used this assay to measure such antibodies in serum from normal subjects and from patients with various neurological conditions. In normal subjects, antibodies to asialo-GM1 were present only in low levels. An arbitrary scale with an upper limit of normal was established. Initial studies have found that abnormally high levels of IgG antibodies to asialo-GM1 were present in 4 of 9 patients with inflammatory demyelinating neuropathies (Guillain-Barré syndrome or chronic inflammatory demyelinating polyradiculoneuropathy). We found one patient with a monoclonal IgM circulating paraprotein and a motor neuropathy who had a high titre of antibody to asialo-GM1. As yet we have found no patients with motor neurone disease with antibodies to asialo-GM1.
Q-Index Code C1
Q-Index Status Provisional Code
Institutional Status Unknown

Document type: Journal Article
Sub-type: Article (original research)
Collection: Scopus Import - Archived
Version Filter Type
Citation counts: Scopus Citation Count Cited 8 times in Scopus Article | Citations
Google Scholar Search Google Scholar
Created: Tue, 28 Jun 2016, 18:15:24 EST by System User