NMR study of the reactions of the cis-diamminediaquaplatinum(II) cation with glutathione and amino acids containing a thiol group

Appleton T.G., Connor J.W., Hall J.R. and Prenzler P.D. (1989) NMR study of the reactions of the cis-diamminediaquaplatinum(II) cation with glutathione and amino acids containing a thiol group. Inorganic Chemistry, 28 11: 2030-2037. doi:10.1021/ic00310a007


Author Appleton T.G.
Connor J.W.
Hall J.R.
Prenzler P.D.
Title NMR study of the reactions of the cis-diamminediaquaplatinum(II) cation with glutathione and amino acids containing a thiol group
Journal name Inorganic Chemistry   Check publisher's open access policy
ISSN 0020-1669
Publication date 1989-01-01
Sub-type Article (original research)
DOI 10.1021/ic00310a007
Volume 28
Issue 11
Start page 2030
End page 2037
Total pages 8
Subject 1604 Human Geography
Abstract 195Pt, 15N, 1H, and 13C NMR spectra have been used to study the reactions between cis-Pt(NH 3) 2(H 2O) 22+ (1) and amino acids containing a thiol group. N-Acetyl-L-cysteine, DL-homocysteine, and glutathione each form a dinuclear complex containing a Pt 2S 2 four-membered ring. Ammonia is slowly lost from these complexes. L-Cysteine (cysH 2) gives a similar complex, together with smaller quantities of cis-Pt(NH 3) 2(SCH 2CH(NH 3)(CO 2H)) 2 2+ and Pt(NH 3) 2(cysH-N,S) +. Penicillamine (penH 2) with 1 in strongly acidic solution gives initially the complex [{Pt(NH 3) 2} 2(penH)] 3+, in which the two Pt atoms are bridged by sulfur and carboxylate. After standing, this complex isomerizes to one in which sulfur still bridges the two Pt atoms, but with one also coordinated by ammine nitrogen and the other by carboxylate oxygen.
Q-Index Code C1
Q-Index Status Provisional Code
Institutional Status Unknown

Document type: Journal Article
Sub-type: Article (original research)
Collection: Scopus Import - Archived
 
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Created: Tue, 28 Jun 2016, 18:03:10 EST by System User