Acetylcholinesterase levels in Angiostrongylus cantonensis in relation to the immune response in rats

Beaver J.-A. and Dobson C. (1978) Acetylcholinesterase levels in Angiostrongylus cantonensis in relation to the immune response in rats. International Journal for Parasitology, 8 1: 9-13. doi:10.1016/0020-7519(78)90044-9


Author Beaver J.-A.
Dobson C.
Title Acetylcholinesterase levels in Angiostrongylus cantonensis in relation to the immune response in rats
Journal name International Journal for Parasitology   Check publisher's open access policy
ISSN 0020-7519
Publication date 1978-01-01
Sub-type Article (original research)
DOI 10.1016/0020-7519(78)90044-9
Volume 8
Issue 1
Start page 9
End page 13
Total pages 5
Subject 2405 Parasitology
2725 Infectious Diseases
Abstract Beaver J. P. and Dobson C. 1978. Acetylcholinesterase levels in Angiostrongylus cantonensis in relation to the immune response in rats. International Journal for Parasitology8: 9-13. Angiostrongylus cantonensis larvae and adult nematodes synthesize three acetylcholinesterase (AChE) isozymes. The Km of this isozyme complex changes with the development and migrations of the parasite in the rat host. The levels of parasite AChE changed as the development of A. cantonensis progressed; increasing quantities of AChE were found in young adult A. cantonensis from the brain of rats. After migration to the pulmonary arteries, the quantity of AChE in the parasite was reduced and continued to decline in the aging parasite. Anti-A. cantonensis antibody inhibited parasite AChE activity; this inhibition of the parasite AChE activity changed at stages during development of the parasite which suggested variation in parasite AChE isozyme levels. Haemagglutinating anti-A. cantonensis antibody appeared in the serum of infected rats when the parasites commenced to lay eggs and increased in titre thereafter until 103 days after infection.
Keyword acetylcholinesterase
Angiostrongylus cantonensis
antienzyme antibody
immunity
isozymes, immunoglobulins
Wistar rats
Q-Index Code C1
Q-Index Status Provisional Code
Institutional Status Unknown

Document type: Journal Article
Sub-type: Article (original research)
Collection: Scopus Import
 
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Created: Tue, 28 Jun 2016, 17:55:26 EST by System User