Pathological changes associated with oesophagostomum columbianum infestations in sheep: Serum protein changes in relation to multiple infestation, intensity of infestation, and immunity

Dobson C. (1967) Pathological changes associated with oesophagostomum columbianum infestations in sheep: Serum protein changes in relation to multiple infestation, intensity of infestation, and immunity. Australian Journal of Agricultural Research, 18 6: 931-945. doi:10.1071/AR9670931


Author Dobson C.
Title Pathological changes associated with oesophagostomum columbianum infestations in sheep: Serum protein changes in relation to multiple infestation, intensity of infestation, and immunity
Journal name Australian Journal of Agricultural Research   Check publisher's open access policy
ISSN 0004-9409
Publication date 1967-01-01
Sub-type Article (original research)
DOI 10.1071/AR9670931
Volume 18
Issue 6
Start page 931
End page 945
Total pages 15
Subject 1100 Agricultural and Biological Sciences
Abstract A relationship between size of infesting dose and multiple infestation and the total serum proteins was demonstrated. During primary infestations with low and medium-sized doses of infective larvae, the total serum proteins fell. After infestation with large larval doses or after multiple infestations the total serum proteins increased.Hypoalbuminaemia could be demonstrated after both primary and secondary infestations; also the animals given secondary infestation had failed to regain the level of serum albumin present before primary infestation.Both α- and β1-globulins of sheep with either first or second infestation retained a level commensurate with, or decreased compared with, that in the control animals. These changes are discussed in relation to osmotic balance of the infected animal.The β2-globulins increased during both primary and secondary infestations: However, the increase was greatest during the primary infestation. Increases in the γ-globulin fraction also occurred but here the greatest increase occurred after secondary infestation. After primary infestation the γ-globulin levels first fell and then increased as the infestation progressed.There was a correlation between the complement fixation, but not the passive haemagglutination, antibody titres and the increased serum β2- and γ-globulin levels. However, the increased γ-globulin levels after secondary infestation were too great to be solely accounted for by an immunological response.
Q-Index Code C1
Q-Index Status Provisional Code
Institutional Status Unknown

Document type: Journal Article
Sub-type: Article (original research)
Collection: Scopus Import
 
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Created: Tue, 28 Jun 2016, 17:46:24 EST by System User