DNA replication and repair in a human melanoma cell-line resistant to ultra-violet-radiation

Lavin M.F., Willett G.M., Chalmers A.H. and Kidson C. (1977) DNA replication and repair in a human melanoma cell-line resistant to ultra-violet-radiation. International Journal of Radiation Biology, 31 2: 101-111. doi:10.1080/09553007714550121


Author Lavin M.F.
Willett G.M.
Chalmers A.H.
Kidson C.
Title DNA replication and repair in a human melanoma cell-line resistant to ultra-violet-radiation
Journal name International Journal of Radiation Biology   Check publisher's open access policy
ISSN 0955-3002
Publication date 1977-01-01
Sub-type Article (original research)
DOI 10.1080/09553007714550121
Open Access Status
Volume 31
Issue 2
Start page 101
End page 111
Total pages 11
Publisher Informa Healthcare
Subject 2741 Radiology Nuclear Medicine and imaging
3614 Radiological and Ultrasound Technology
1101 Medical Biochemistry and Metabolomics
2104 Nuclear Energy and Engineering
3108 Radiation
Abstract The effect of ultra-violet (U.V.)-irradiation on DNA replication was studied in a U.V.-resistant, human melanoma cell-line (MM96). Semi-conservative synthesis of DNA was decreased about five-fold by a U.V.-dose of 100 ergs/mm2. The size of DNA fragments synthesized in irradiated cells at short times after U.V. was smaller than those synthesized in unirradiated cells. Elongation of these fragments occurred with time, and 6 hours after irradiation cells synthesized DNA in fragments of the same size as obtained in unirradiated cells. In this post-replication repair process, elongation appeared to involve de novo synthesis and was not inhibited by theophylline.
Q-Index Code C1
Q-Index Status Provisional Code
Institutional Status Unknown

Document type: Journal Article
Sub-type: Article (original research)
Collection: Scopus Import - Archived
 
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Created: Tue, 28 Jun 2016, 17:45:08 EST by System User