Plasma protein binding of diphenylhydantoin effects of sex hormones, renal and hepatic disease

Hooper W.D., Bochner F., Eadie M.J. and Tyrer J.H. (1974) Plasma protein binding of diphenylhydantoin effects of sex hormones, renal and hepatic disease. Clinical Pharmacology and Therapeutics, 15 3: 276-282.

Author Hooper W.D.
Bochner F.
Eadie M.J.
Tyrer J.H.
Title Plasma protein binding of diphenylhydantoin effects of sex hormones, renal and hepatic disease
Journal name Clinical Pharmacology and Therapeutics   Check publisher's open access policy
ISSN 0009-9236
Publication date 1974-01-01
Sub-type Article (original research)
Volume 15
Issue 3
Start page 276
End page 282
Total pages 7
Subject 3004 Pharmacology
2736 Pharmacology (medical)
Abstract The in vitro binding of diphenylhydantoin (DPH) to the protein in plasma from 97 volunteers has been studied using ultrafiltration at 37° C. The capacity of plasma protein to bind DPH did not differ significantly between pregnant women (11.6 ± 1.7% of total drug unbound), women taking oral contraceptives (9.9 ± 1.7% unbound), healthy males (10.6 ± 1.3% unbound), and healthy females (11.0 ± 3.2% unbound). However, in plasma from patients with renal disease (15.8 ± 3.9% unbound), hepatic disease (15.9 ∥ 6.0%) or hepatorenal disease (15.6 ± 5.4%), the protein binding of DPH was significantly decreased. These changes in protein binding were found to correlate better with changes in albumin and bilirubin levels in plasma than with any o f 13 other biochemical parameters examined.
Q-Index Code C1
Q-Index Status Provisional Code
Institutional Status Unknown

Document type: Journal Article
Sub-type: Article (original research)
Collection: Scopus Import
 
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Created: Tue, 28 Jun 2016, 17:40:50 EST by System User