Evidence that the efficacy (intrinsic activity) of fenoterol is higher than that of salbutamol on β-adrenoceptors in guinea-pig trachea

O'Donnell S.R. and Wanstall J.C. (1978) Evidence that the efficacy (intrinsic activity) of fenoterol is higher than that of salbutamol on β-adrenoceptors in guinea-pig trachea. European Journal of Pharmacology, 47 3: 333-340. doi:10.1016/0014-2999(78)90241-8


Author O'Donnell S.R.
Wanstall J.C.
Title Evidence that the efficacy (intrinsic activity) of fenoterol is higher than that of salbutamol on β-adrenoceptors in guinea-pig trachea
Journal name European Journal of Pharmacology   Check publisher's open access policy
ISSN 0014-2999
Publication date 1978-02-01
Sub-type Article (original research)
DOI 10.1016/0014-2999(78)90241-8
Volume 47
Issue 3
Start page 333
End page 340
Total pages 8
Subject 2804 Cellular and Molecular Neuroscience
3004 Pharmacology
Abstract The functional antagonism of carbachol by fenoterol and salbutamol (β-adrenoceptor agonists) has been used to demonstrate that the efficacy (intrinsic activity) of fenoterol was about twice that of salbutamol on guinea-pig trachea. The mean maximum shifts of the carbachol concentration-response lines by fenoterol and salbutamol were (log units) 1.07 ± 0.07 (n = 5) and 0.64 ± 0.07 (n = 5) respectively. This difference in their efficacies could be demonstrated as differences in maximum relaxation on tracheal preparations contracted with carbachol, although this was dependent on the concentration of carbachol used. β-Adrenoceptor blocking properties of salbutamol (1 mM) but not fenoterol (1 mM) could be demonstrated on trachea in that salbutamol, but not fenoterol, antagonised the shift in the carbachol concentration-response line produced by isoprenaline. The implications of these findings in relation to the use of fenoterol and salbutamol as bronchodilators is discussed.
Keyword Efficacies, relative
Fenoterol
Guinea-pig trachea
Salbutamol
β-Adrenoceptors
Q-Index Code C1
Q-Index Status Provisional Code
Institutional Status Unknown

Document type: Journal Article
Sub-type: Article (original research)
Collection: Scopus Import
 
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Created: Tue, 28 Jun 2016, 17:33:36 EST by System User