Abnormal amino acid analyses obtained from osteogenesis imperfecta dentin.

Gage J.P., Francis M.J. and Smith R. (1988) Abnormal amino acid analyses obtained from osteogenesis imperfecta dentin.. Journal of Dental Research, 67 8: 1097-1102. doi:10.1177/00220345880670080701

Author Gage J.P.
Francis M.J.
Smith R.
Title Abnormal amino acid analyses obtained from osteogenesis imperfecta dentin.
Journal name Journal of Dental Research   Check publisher's open access policy
ISSN 0022-0345
Publication date 1988-01-01
Sub-type Article (original research)
DOI 10.1177/00220345880670080701
Open Access Status Not yet assessed
Volume 67
Issue 8
Start page 1097
End page 1102
Total pages 6
Language eng
Subject 3500 Dentistry
Abstract Amino acid analyses were carried out on dentin proteins obtained from 33 normal teeth and 59 teeth from osteogenesis imperfecta patients. The analyses revealed that in the control teeth approximately 95% of the insoluble dentin fraction was collagen. The majority of the analyses for teeth obtained from the O.I. patients were biochemically abnormal (55 out of 59). Specifically, there was a significant increase in the acidic amino acids, with a corresponding decrease in the basic amino acids. A small group of patients showed double peaks in the histidine, hydroxylysine, and lysine areas of the chromatograms. These results emphasize that despite the fact that the teeth of O.I. patients may appear to be clinically normal, all but four of the teeth examined had abnormal dentin collagen.
Q-Index Code C1
Q-Index Status Provisional Code
Institutional Status Unknown

Document type: Journal Article
Sub-type: Article (original research)
Collection: Scopus Import - Archived
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