Recent advances in the diagnosis and management of giardiasis

Shepherd R.W. and Boreham P.F.L. (1989) Recent advances in the diagnosis and management of giardiasis. Scandinavian Journal of Gastroenterology, 24 S169: 60-64. doi:10.3109/00365528909091334


Author Shepherd R.W.
Boreham P.F.L.
Title Recent advances in the diagnosis and management of giardiasis
Journal name Scandinavian Journal of Gastroenterology   Check publisher's open access policy
ISSN 0036-5521
Publication date 1989-01-01
Sub-type Article (original research)
DOI 10.3109/00365528909091334
Volume 24
Issue S169
Start page 60
End page 64
Total pages 5
Publisher Informa Healthcare
Subject 2715 Gastroenterology
Abstract Management of patients with giardiasis is often difficult because of problems related to diagnosis, lack of knowledge about pathophysiology, and a less than satisfactory chemotherapeutic armamentarium. Treatment, particularly in children, presents several problems: What drug should be used, and at what dosage? Should the patient's contacts be treated? How does one cope with treatment failures? An overview of data available in the literature is presented, and studies on the susceptibility and resistance of Giardia isolates to different drugs in in vitro and in vivo models are discussed. In such models, tinidazole, metronidazole, and furazolidone were most active in terms of susceptibility; quinacrine was least active. However, Giardia strains resistant to all four drugs were isolated. Nitroimidazoles were associated with poor compliance in children, whereas furazolidone was well tolerated. It is concluded that management of symptomatic giardiasis is complicated by a range of factors, including drug resistance, patient compliance, and the lack of an accurate, sensitive, and noninvasive diagnostic test.
Keyword Drug resistance
Furazolidone
Giardiasis
Metronidazole
Patient compliance
Quinacrine
Tinidazole
Q-Index Code C1
Q-Index Status Provisional Code
Institutional Status Unknown

Document type: Journal Article
Sub-type: Article (original research)
Collection: Scopus Import
 
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