Blocking and unblocking of cell-mediated anti-tumor immunity in mice, as detected by the leucocyte adherence inhibition test

Halliday W.J., Maluish A. and Miller S. (1974) Blocking and unblocking of cell-mediated anti-tumor immunity in mice, as detected by the leucocyte adherence inhibition test. Cellular Immunology, 10 3: 467-475. doi:10.1016/0008-8749(74)90138-5


Author Halliday W.J.
Maluish A.
Miller S.
Title Blocking and unblocking of cell-mediated anti-tumor immunity in mice, as detected by the leucocyte adherence inhibition test
Journal name Cellular Immunology   Check publisher's open access policy
ISSN 1090-2163
Publication date 1974-03-15
Sub-type Article (original research)
DOI 10.1016/0008-8749(74)90138-5
Open Access Status
Volume 10
Issue 3
Start page 467
End page 475
Total pages 9
Subject 1307 Cell Biology
2403 Immunology
Abstract Further observations have been made using the in vitro leucocyte adherence inhibition (LAI) test previously described. The test has been slightly modified and shown to give highly reproducible results in detecting cell-mediated immunity in peritoneal cells of mice exposed to tumors, and in demonstrating factors which modify this immunity. Two different methylcholanthrene-induced tumors stimulated specific reactivity in their hosts as shown by the leucocyte adherence inhibition test employing soluble tumor extracts as antigens. When serum from tumor-bearing mice was added to the mixture, reactivity was specifically blocked. Serum from mice after tumor removal lacked the ability to block the leucocyte adherence inhibition reaction, but specifically reversed the effect of blocking serum (unblocking). Thus three important phenomena of tumor immunity, previously discovered by tedious and complex techniques, are now detectable by a brief, simple procedure.
Q-Index Code C1
Q-Index Status Provisional Code
Institutional Status Unknown

Document type: Journal Article
Sub-type: Article (original research)
Collection: Scopus Import - Archived
 
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Created: Tue, 28 Jun 2016, 16:26:53 EST by System User