The effect of prostaglandin inhibition on the development of pulmonary pathology associated with dead Dirofilaria immitis

Tarish J.H. and Atwell R.B. (1993) The effect of prostaglandin inhibition on the development of pulmonary pathology associated with dead Dirofilaria immitis. Veterinary Parasitology, 49 2-4: 207-217. doi:10.1016/0304-4017(93)90120-C


Author Tarish J.H.
Atwell R.B.
Title The effect of prostaglandin inhibition on the development of pulmonary pathology associated with dead Dirofilaria immitis
Journal name Veterinary Parasitology   Check publisher's open access policy
ISSN 0304-4017
Publication date 1993-01-01
Sub-type Article (original research)
DOI 10.1016/0304-4017(93)90120-C
Volume 49
Issue 2-4
Start page 207
End page 217
Total pages 11
Subject 1103 Clinical Sciences
2405 Parasitology
3400 Veterinary
Abstract Flunixin meglumine was used to examine the effect of prostaglandin inhibition on the pathogenesis of Dirofilaria immitis in the pulmonary arteries of dogs. Immunopathological reactions to dead filariae were monitored by light and transmission electron microscopy and serology. Lung lesions in prostaglandin-inhibited dogs exposed to dead filariae were enhanced compared to control dogs. This was associated with the persistence of parasitic antigen in lung tissue and in the blood. Serology demonstrated that after insertion of D. immitis in treated dogs, antibody levels did not change, while immune complex and antigen levels increased. These results indicate that prostaglandin may have a protective effect on the way the lung reacts to dead D. immitis, and that altered dynamics of the antigen processing may well contribute to the associated lung lesions.
Q-Index Code C1
Q-Index Status Provisional Code
Institutional Status Unknown

Document type: Journal Article
Sub-type: Article (original research)
Collection: Scopus Import - Archived
 
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Created: Tue, 28 Jun 2016, 16:14:44 EST by System User