The mechanism of enhancement of the neurogenic oedema response by baclofen

Belinda Walker S. and Chahl L.A. (1980) The mechanism of enhancement of the neurogenic oedema response by baclofen. European Journal of Pharmacology, 62 1: 27-34. doi:10.1016/0014-2999(80)90477-X


Author Belinda Walker S.
Chahl L.A.
Title The mechanism of enhancement of the neurogenic oedema response by baclofen
Journal name European Journal of Pharmacology   Check publisher's open access policy
ISSN 0014-2999
Publication date 1980-03-07
Sub-type Article (original research)
DOI 10.1016/0014-2999(80)90477-X
Open Access Status Not yet assessed
Volume 62
Issue 1
Start page 27
End page 34
Total pages 8
Subject 2804 Cellular and Molecular Neuroscience
3004 Pharmacology
Abstract The effect of baclofen on the neurogenic oedema response to electrical stimulation of the saphenouse nerve in rats was investigated. Baclofen 2.5 × 10-6 mol given intravenously enhanced the neurogenic oedema response and increased blood pressurre. The enhancement was not specific to the neurogenic oedema response since plasma exudation responses to substance P, histamine and 5-hydroxytryptamine were also enhanced. No local interactions between baclofen and agents inducing plasma exudation were found which would account for this effect of baclofen. Since agents which abolished the pressor response to baclofen (α- and β-adrenoceptor antagonists, hexamethonium, reserpine) also abolished the enhancement of neurogenic oedema, it was concluded that baclofen enhanced the response by its action on the cardiovascular system.
Keyword Baclofen
Cardiovascular system
Neurogenic oedema
Plasma exudation
Substance P
Q-Index Code C1
Q-Index Status Provisional Code
Institutional Status Unknown

Document type: Journal Article
Sub-type: Article (original research)
Collection: Scopus Import - Archived
 
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Created: Tue, 28 Jun 2016, 14:50:26 EST by System User