How important is the myeloperoxidase microbicidal system of phagocytic cells?

Thong Y.H. (1982) How important is the myeloperoxidase microbicidal system of phagocytic cells?. Medical Hypotheses, 8 3: 249-254. doi:10.1016/0306-9877(82)90120-7


Author Thong Y.H.
Title How important is the myeloperoxidase microbicidal system of phagocytic cells?
Journal name Medical Hypotheses   Check publisher's open access policy
ISSN 0306-9877
Publication date 1982-01-01
Sub-type Article (original research)
DOI 10.1016/0306-9877(82)90120-7
Open Access Status Not yet assessed
Volume 8
Issue 3
Start page 249
End page 254
Total pages 6
Subject 1309 Developmental Biology
2700 Medicine
3002 Drug Discovery
Abstract The myeloperoxidase system is presented by most immunology textbooks as a major microbicidal system of phagocytic cells. This theory, however, has not been subjected to vigorous testing in the clinical arena. Of 14 patients with primary myeloperoxidase deficiency, only 3 had infectious complication. All 3 patients have more plausible explanations than myeloperoxidase deficiency for their infectious complications. Two of these patients were healthy until middle age when they developed systemic candidiasis after the onset of diabetes mellitus. The third patient was an infant with a maturational defect in neutrophil chemotaxis whose infectious complications ceased after the normalization of the chemotactic defect. The results of these "experiments of nature" indicate that the meyloperoxidase system is not a major microbicidal mechanism of phagocytic cells.
Q-Index Code C1
Q-Index Status Provisional Code
Institutional Status Unknown

Document type: Journal Article
Sub-type: Article (original research)
Collection: Scopus Import - Archived
 
Versions
Version Filter Type
Citation counts: Scopus Citation Count Cited 7 times in Scopus Article | Citations
Google Scholar Search Google Scholar
Created: Tue, 28 Jun 2016, 14:50:15 EST by System User