Estimation of all parameters from nonisothermal kinetic data

Tucker I.G. and Owen W.R. (1982) Estimation of all parameters from nonisothermal kinetic data. Journal of Pharmaceutical Sciences, 71 9: 969-974. doi:10.1002/jps.2600710903

Author Tucker I.G.
Owen W.R.
Title Estimation of all parameters from nonisothermal kinetic data
Journal name Journal of Pharmaceutical Sciences   Check publisher's open access policy
ISSN 0022-3549
Publication date 1982-01-01
Sub-type Article (original research)
DOI 10.1002/jps.2600710903
Open Access Status Not yet assessed
Volume 71
Issue 9
Start page 969
End page 974
Total pages 6
Language eng
Subject 1313 Molecular Medicine
1600 Chemistry
1605 Policy and Administration
3002 Drug Discovery
3003 Pharmaceutical Science
3004 Pharmacology
Abstract A method is described which estimates (using least‐squares analysis) all parameters (kinetic parameters and also zero and infinite time assays) from nonisothermal kinetic data. This method overcomes the time delays required for infinite time assays and biased estimates caused by the use of those assay results. Flexible temperature and data collection programs can be used. The mathematical models account for thermal volume expansion and the appropriate model is selected by statistical tests (provided the reaction is studied over ∼90% decomposition). The models use a reparameterized Arrhenius equation in which the frequency factor is replaced by k, the rate constant at a specified temperature. This improves the numerical procedure and allows room temperature stability to be estimated directly. Copyright
Keyword Drug stability—estimation from nonisothermal kinetic data
Kinetics—estimation of all parameters from nonisothermal data
Models, mathematical—estimation of all parameters from nonisothermal kinetic data
Q-Index Code C1
Q-Index Status Provisional Code
Institutional Status Unknown

Document type: Journal Article
Sub-type: Article (original research)
Collection: Scopus Import - Archived
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Citation counts: Scopus Citation Count Cited 13 times in Scopus Article | Citations
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Created: Tue, 28 Jun 2016, 14:47:10 EST by System User