Excitatory synaptic transmission in the lateral and central amygdala

Sah, P. and De Armentia, M. L. (2003) Excitatory synaptic transmission in the lateral and central amygdala. Annals of New York Academy of Sciences, 985 THE AMYGDALA IN BRAIN FUNCTION Basic and Clinical Approaches: 67-77. doi:10.1111/j.1749-6632.2003.tb07072.x


Author Sah, P.
De Armentia, M. L.
Title Excitatory synaptic transmission in the lateral and central amygdala
Journal name Annals of New York Academy of Sciences   Check publisher's open access policy
ISSN 0077-8923
ISBN 1-57331-404-8
Publication date 2003-01-01
Sub-type Article (original research)
DOI 10.1111/j.1749-6632.2003.tb07072.x
Volume 985
Issue THE AMYGDALA IN BRAIN FUNCTION Basic and Clinical Approaches
Start page 67
End page 77
Total pages 11
Place of publication New York
Publisher New York Acad Sciences
Language eng
Subject 11 Medical and Health Sciences
1109 Neurosciences
Abstract The amygdala plays a major role in the acquisition and expression of fear conditioning. NMDA receptor-dependent synaptic plasticity within the basolateral amygdala has been proposed to underlie the acquisition and possible storage of fear memories. Here the properties of fast glutamatergic transmission in the lateral and central nuclei of the amygdala are presented. In the lateral amygdala, two types of neurons, interneurons and projection neurons, could be distinguished by their different firing properties. Glutamatergic inputs to interneurons activated AMPA receptors with inwardly rectifying current-voltage relations (I-Vs), whereas inputs to projection neurons activated receptors that had linear I-Vs, indicating that receptors on interneurons lack GluR2 subunits. Inputs to projection neurons formed dual component synapses with both AMPA and NMDA components, whereas at inputs to interneurons, the contribution of NMDA receptors was very small. Neurons in the central amygdala received dual component glutamatergic inputs that activated AMPA receptors with linear I-Vs. NMDA receptor-mediated EPSCs had slow decay time constants in the central nucleus. Application of NR2B selective blockers ifenprodil or CP-101,606 blocked NMDA EPSCs by 70% in the central nucleus, but only by 30% in the lateral nucleus. These data show that the distribution of glutamatergic receptors on amygdalar neurons is not uniform. In the lateral amygdala, interneurons and pyramidal neurons express AMPA receptors with different subunit compositions. Synapses in the central nucleus activate NMDA receptors that contain NR1 and NR2B subunits, whereas synapses in the lateral nucleus contain receptors with both NR2A and NR2B subunits.
Keyword Multidisciplinary Sciences
Nmda
Ampa
Amygdala
Fear
Ltp
Glutamate-receptor Channels
Rat Basolateral Amygdala
Nmda Receptors
Ampa Receptors
Neocortical Neurons
Subunit Expression
Hippocampal Slices
Principal Neurons
Ca2+ Permeability
Visual-cortex
Q-Index Code C1
Q-Index Status Provisional Code
Institutional Status Unknown

Document type: Journal Article
Sub-type: Article (original research)
Collections: Excellence in Research Australia (ERA) - Collection
Queensland Brain Institute Publications
 
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Created: Mon, 13 Aug 2007, 23:33:56 EST