IGF-2 stimulates growth and metabolism of early mouse embryos

Harvey M.B. and Kaye P.L. (1992) IGF-2 stimulates growth and metabolism of early mouse embryos. Mechanisms of Development, 38 3: 169-173. doi:10.1016/0925-4773(92)90050-T

Author Harvey M.B.
Kaye P.L.
Title IGF-2 stimulates growth and metabolism of early mouse embryos
Journal name Mechanisms of Development   Check publisher's open access policy
ISSN 0925-4773
Publication date 1992-01-01
Sub-type Article (original research)
DOI 10.1016/0925-4773(92)90050-T
Volume 38
Issue 3
Start page 169
End page 173
Total pages 5
Language eng
Subject 1309 Developmental Biology
2806 Developmental Neuroscience
Abstract Recent reports indicate that the insulin gene family plays a significant role in early development. Both insulin and IGF-1 stimulate growth and metabolism in preimplantation mouse embryos, however, little is known of the physiological effects of IGF-2. In this study, addition of IGF-2 to defined culture medium for the culture of 2-cell embryos stimulated blastocyst formation by 15%, ICM mitogenesis by 37%, and protein synthesis by 35%. EC50s of 12-63 pM IGF-2 for these responses were in the range for mediation by IGF-2 receptors. These results coupled with the previously demonstrated presence and expression of the IGF-2 receptor from the 2-cell stage supports a role for this third member of the insulin gene family in early development.
Keyword Embryo
Q-Index Code C1
Q-Index Status Provisional Code
Institutional Status Unknown

Document type: Journal Article
Sub-type: Article (original research)
Collection: Scopus Import
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Citation counts: Scopus Citation Count Cited 48 times in Scopus Article | Citations
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Created: Tue, 28 Jun 2016, 14:06:41 EST by System User