Influence of carrier moisture adsorption capacity on the degree of adhesion of interactive mixtures

Padmadisastra Y., Kennedy R.A. and Stewart P.J. (1994) Influence of carrier moisture adsorption capacity on the degree of adhesion of interactive mixtures. International Journal of Pharmaceutics, 104 1: . doi:10.1016/0378-5173(94)90341-7


Author Padmadisastra Y.
Kennedy R.A.
Stewart P.J.
Title Influence of carrier moisture adsorption capacity on the degree of adhesion of interactive mixtures
Journal name International Journal of Pharmaceutics   Check publisher's open access policy
ISSN 0378-5173
Publication date 1994-04-08
Sub-type Article (original research)
DOI 10.1016/0378-5173(94)90341-7
Volume 104
Issue 1
Total pages 1
Subject 3003 Pharmaceutical Science
Abstract The interaction of sulphathiazole and succinylsulphathiazole with Compactrol®, TabBase®, Emdex® and lactose granules was studied. Carriers with a high capacity to adsorb moisture caused a significant increase in the adhesion when the mixtures were stored under high humidity conditions. The effect was attributed to capillary interaction following liquid bridge formation between the drug and carrier surfaces. Oven drying of the moist mixtures further increased the degree of adhesion probably due to solid bridge formation.
Keyword Capillary interaction
Crystal bridge
Interactive mixing
Particle adhesion
Solid bridging
Q-Index Code C1
Q-Index Status Provisional Code
Institutional Status Unknown

Document type: Journal Article
Sub-type: Article (original research)
Collection: Scopus Import - Archived
 
Versions
Version Filter Type
Citation counts: Scopus Citation Count Cited 14 times in Scopus Article | Citations
Google Scholar Search Google Scholar
Created: Tue, 28 Jun 2016, 13:45:26 EST by System User