Development and behaviour of a strain of bovine ephemeral fever virus with unusual host range

Tzipori S. and Spradbrow P.B. (1974) Development and behaviour of a strain of bovine ephemeral fever virus with unusual host range. Journal of Comparative Pathology, 84 1: 1-8. doi:10.1016/0021-9975(74)90021-8


Author Tzipori S.
Spradbrow P.B.
Title Development and behaviour of a strain of bovine ephemeral fever virus with unusual host range
Journal name Journal of Comparative Pathology   Check publisher's open access policy
ISSN 0021-9975
Publication date 1974-01-01
Sub-type Article (original research)
DOI 10.1016/0021-9975(74)90021-8
Open Access Status Not yet assessed
Volume 84
Issue 1
Start page 1
End page 8
Total pages 8
Subject 1103 Clinical Sciences
Abstract A strain of bovine ephemeral fever virus which proved to be pathogenic to both cattle and mice was developed by alternating passages through cattle and mice. This strain in the first passage killed baby mice within 3 days as compared with 4 to 5 days of the third passage for the wild strain. The third baby mouse brain passage of this virus, designated 525 MBP3, was pathogenic to adult mice, day-old guinea pigs, baby rats, and 3-day-old kittens when inoculated intracerebrally, and to 10 and 11-day-old chicken embryos when inoculated intravenously. Infected adult mice and guinea-pigs developed bilateral conjunctivitis shortly before death, while infected chicken embryos after hatching showed varying degrees of ataxia and inco-ordination. The virus was re-isolated from the brains of chickens in baby mice. Strain 525 MBP3 had a titre of 106·5LD50 0·02 ml. of brain suspension. It might prove to be a useful strain in the development of a better vaccine and in the study of the pathogenesis of this disease in cattle.
Q-Index Code C1
Q-Index Status Provisional Code
Institutional Status Unknown

Document type: Journal Article
Sub-type: Article (original research)
Collection: Scopus Import - Archived
 
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