Cell-mediated immunity to liver antigen in toxic liver injury. I. Occurrence and specificity

Smith C.I., Cooksley W.G.E. and Powell L.W. (1980) Cell-mediated immunity to liver antigen in toxic liver injury. I. Occurrence and specificity. Clinical and Experimental Immunology, 39 3: 607-617.

Author Smith C.I.
Cooksley W.G.E.
Powell L.W.
Title Cell-mediated immunity to liver antigen in toxic liver injury. I. Occurrence and specificity
Journal name Clinical and Experimental Immunology   Check publisher's open access policy
ISSN 0009-9104
Publication date 1980-01-01
Sub-type Article (original research)
Open Access Status Not yet assessed
Volume 39
Issue 3
Start page 607
End page 617
Total pages 11
Language eng
Subject 2403 Immunology
Abstract To investigate the possible role of cell-mediated immunity in the pathogenesis of liver disease lymphocyte function was studied in CBA mice in which predictable sublethal liver necrosis had been included by the administration of the hepatotoxin carbon tetrachloride (CCl). Non-specific lymphocyte function, as assessed by the response to the mitogen phytohaemagglutinin (PHA) was normal in over 90% of the animals. Forty-three per cent of the treated mice demonstrated specific lymphocytes sensitivity to liver antigen preparations. Such specific sensitivity was transient and apparent in only one case for more than 2 weeks after the CCl treatment. The lymphocyte sensitization was not reproduced by the addition of CCl to the lymphocyte cultures. There was no correlation between the severity of the liver disease and the detection of sensitized lymphocytes. Although these data may not be extrapolated directly to human liver disease, they demonstrate that cell-mediated immune reactivity to liver-derived antigens can occur as a result of non-immunological toxic liver injury.
Q-Index Code C1
Q-Index Status Provisional Code
Institutional Status Unknown

Document type: Journal Article
Sub-type: Article (original research)
Collection: Scopus Import - Archived
 
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Created: Tue, 28 Jun 2016, 11:26:57 EST by System User