Differing effects of electrical and chemical parabrachial nucleus stimulation on supraoptic vasopressin cells

Day T.A. and Sibbald J.R. (1993) Differing effects of electrical and chemical parabrachial nucleus stimulation on supraoptic vasopressin cells. Journal of the Autonomic Nervous System, 45 2: 175-179. doi:10.1016/0165-1838(93)90129-I


Author Day T.A.
Sibbald J.R.
Title Differing effects of electrical and chemical parabrachial nucleus stimulation on supraoptic vasopressin cells
Journal name Journal of the Autonomic Nervous System   Check publisher's open access policy
ISSN 0165-1838
Publication date 1993-01-01
Sub-type Article (original research)
DOI 10.1016/0165-1838(93)90129-I
Open Access Status Not yet assessed
Volume 45
Issue 2
Start page 175
End page 179
Total pages 5
Subject 1314 Physiology
2728 Clinical Neurology
2800 Neuroscience
Abstract Electrical stimulation of the parabrachial nucleus stimulates vasopressin secretion. To determine whether this is due to activation of intrinsic projection neurons or fibers of passage we compared, in anaesthetized rats, the effects of electrical and chemical parabrachial nucleus stimulation on the activity of neurosecretory vasopressin cells of the supraoptic nucleus. Electrical stimulation excited 35% and inhibited 14% of vasopressin cells tested (257 tests). Parabrachial nucleus injections of the neuroexcitant glutamate (0.2, 10 or 200 mM) altered the activity of only 6% of vasopressin cells tested (118 tests). At the highest glutamate concentration, which produced clear changes in blood pressure, all responsive units were inhibited (4/22 cells). These data suggest that previous reports indicating a facilitatory role for parabrachial nucleus neurons in the regulation of vasopressin secretion are likely to be attributable to effects on fibers of passage.
Keyword Neurosecretory cell
Parabrachial nucleus
Supraoptic nucleus
Vasopressin
Q-Index Code C1
Q-Index Status Provisional Code
Institutional Status Unknown

Document type: Journal Article
Sub-type: Article (original research)
Collection: Scopus Import - Archived
 
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