Solid bridge formation in sulphonamide-Emdex interactive systems

Padmadisastra Y., Kennedy R.A. and Stewart P.J. (1994) Solid bridge formation in sulphonamide-Emdex interactive systems. International Journal of Pharmaceutics, 112 1: 55-63. doi:10.1016/0378-5173(94)90261-5

Author Padmadisastra Y.
Kennedy R.A.
Stewart P.J.
Title Solid bridge formation in sulphonamide-Emdex interactive systems
Journal name International Journal of Pharmaceutics   Check publisher's open access policy
ISSN 0378-5173
Publication date 1994-11-04
Sub-type Article (original research)
DOI 10.1016/0378-5173(94)90261-5
Volume 112
Issue 1
Start page 55
End page 63
Total pages 9
Language eng
Subject 3003 Pharmaceutical Science
Abstract Solid bridge formation in model sulphathiazole and succinylsulphathiazole-Emdex® interactive systems was studied. Changes in adhesion during fluidized column drying were attributed to solid bridge formation caused by the deposition of dissolved material between the adhered sulphonamide particle and carrier surface reinforcing the interaction. The formation of the solid bridges was dependent on the moisture content of Emdex® in the predried mixture with adhesion reaching a maximum at a moisture content of 10.5%. The capillary interaction which occurred in the moist mixtures and preceded the solid bridge formation was generally stronger than the adhesion due to solid bridging. Consideration of the adhesion profile changes and interactive behaviour during storage provided indirect evidence of solid bridge formation. Both capillary interaction and solid bridging were influenced by the particle size of the drug with the smallest particles being most strongly adhered.
Keyword Capillary interaction
Interactive mixing
Ordered mixing
Particle adhesion
Solid bridging
Q-Index Code C1
Q-Index Status Provisional Code
Institutional Status Unknown

Document type: Journal Article
Sub-type: Article (original research)
Collection: Scopus Import - Archived
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Citation counts: TR Web of Science Citation Count  Cited 11 times in Thomson Reuters Web of Science Article | Citations
Scopus Citation Count Cited 11 times in Scopus Article | Citations
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