Childhood cancer incidence in Queensland, 1979-88

McWhirter W.R. and Petroeschevsky A.L. (1990) Childhood cancer incidence in Queensland, 1979-88. International Journal of Cancer, 45 6: 1002-1005. doi:10.1002/ijc.2910450603


Author McWhirter W.R.
Petroeschevsky A.L.
Title Childhood cancer incidence in Queensland, 1979-88
Journal name International Journal of Cancer   Check publisher's open access policy
ISSN 0020-7136
Publication date 1990-01-01
Year available 2017
Sub-type Article (original research)
DOI 10.1002/ijc.2910450603
Open Access Status Not Open Access
Volume 45
Issue 6
Start page 1002
End page 1005
Total pages 4
Publisher WILEY
Language eng
Subject 1306 Cancer Research
2730 Oncology
Abstract Cancer risk is increased substantially in adult kidney transplant recipients, but the long-term risk of cancer in childhood recipients is unclear. Using the Australian and New Zealand Dialysis and Transplant Registry, the authors compared overall and site-specific incidences of cancer after transplantation in childhood recipients with population-based data by using standardized incidence ratios (SIRs). Among 1734 childhood recipients (median age 14 years, 57% male, 85% white), 289 (16.7%) developed cancer (196 nonmelanoma skin cancers, 143 nonskin cancers) over a median follow-up of 13.4 years. The 25-year cumulative incidences of any cancer were 27% (95% confidence intervals 24-30%), 20% (17-23%) for nonmelanoma skin cancer, and 14% (12-17%) for nonskin cancer (including melanoma). The SIR for nonskin cancer was 8.23 (95% CI 6.92-9.73), with the highest risk for posttransplant lymphoproliferative disease (SIR 45.80, 95% CI 32.71-62.44) and cervical cancer (29.4, 95% CI 17.5-46.5). Increasing age at transplantation (adjusted hazard ratio [aHR] per year 1.10, 95% CI 1.06-1.14), white race (aHR 3.36, 95% CI 1.61-6.79), and having a functioning transplant (aHR 2.27, 95% CI 1.47-3.71) were risk factors for cancer. Cancer risk, particularly for virus-related cancers, is increased substantially after kidney transplantation during childhood.
Keyword cancer/malignancy/neoplasia: registry/incidence
cancer/malignancy/neoplasia: risk factors
clinical research/practice
kidney transplantation/nephrology
pediatrics
Q-Index Code C1
Q-Index Status Provisional Code
Institutional Status Unknown

Document type: Journal Article
Sub-type: Article (original research)
Collection: Scopus Import - Archived
 
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Citation counts: TR Web of Science Citation Count  Cited 11 times in Thomson Reuters Web of Science Article | Citations
Scopus Citation Count Cited 10 times in Scopus Article | Citations
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