Early events associated with experimental infection of the murine lung with Rhodococcus equi

Bowles P.M., Woolcock J.B. and Mutimer M.D. (1989) Early events associated with experimental infection of the murine lung with Rhodococcus equi. Journal of Comparative Pathology, 101 4: 411-420. doi:10.1016/0021-9975(89)90024-8


Author Bowles P.M.
Woolcock J.B.
Mutimer M.D.
Title Early events associated with experimental infection of the murine lung with Rhodococcus equi
Journal name Journal of Comparative Pathology   Check publisher's open access policy
ISSN 0021-9975
Publication date 1989-01-01
Sub-type Article (original research)
DOI 10.1016/0021-9975(89)90024-8
Open Access Status
Volume 101
Issue 4
Start page 411
End page 420
Total pages 10
Subject 1103 Clinical Sciences
Abstract Pneumonia due to Rhodococcus equi was induced in the murine lung by deposition of a known dose of organisms. From serial estimations of bacterial numbers in the lungs of inoculated mice, analysis of the cellular composition of bronchoalveolar lavage fluid and morphological examination of the lungs, events in the host-parasite interaction were followed until day 7. Early bacterial clearance from the lung was dose-dependent but was not sustained. A proportion of the inoculated R. equi was susceptible to the early nonspecific phagocytic cell response, and the contribution of neutrophils to bacterial clearance appeared largely limited to the first 24 hours. A substantial fraction of the organisms survived in the alveoli, probably within macrophages. The contribution phagocytes make to resistance against R. equi is similar to that which prevails in infection with Listeria monocytogenes.
Q-Index Code C1
Q-Index Status Provisional Code
Institutional Status Unknown

Document type: Journal Article
Sub-type: Article (original research)
Collection: Scopus Import - Archived
 
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Citation counts: TR Web of Science Citation Count  Cited 8 times in Thomson Reuters Web of Science Article | Citations
Scopus Citation Count Cited 9 times in Scopus Article | Citations
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