Genetic variants associated with subjective well-being, depressive symptoms, and neuroticism identified through genome-wide analyses

Okbay, Aysu, Baselmans, Bart M. L., De Neve, Jan-Emmanuel, Turley, Patrick, Nivard, Michel G., Fontana, Mark Alan, Meddens, S. Fleur W., Linner, Richard Karlsson, Rietveld, Cornelius A., Derringer, Jaime, Gratten, Jacob, Lee, James J., Liu, Jimmy Z., de Vlaming, Ronald, Ahluwalia, Tarunveer S., Buchwald, Jadwiga, Cavadino, Alana, Frazier-Wood, Alexis C., Furlotte, Nicholas A., Garfield, Victoria, Geisel, Marie Henrike, Gonzalez, Juan R., Haitjema, Saskia, Karlsson, Robert, van der Laan, Sander W., Ladwig, Karl-Heinz, Lahti, Jari, van der Lee, Sven J., Lind, Penelope A., Liu, Tian, Matteson, Lindsay, Mihailov, Evelin, Miller, Michael B., Minica, Camelia C., Nolte, Ilja M., Mook-Kanamori, Dennis, van der Most, Peter J., Oldmeadow, Christopher, Qian, Yong, Raitakari, Olli, Rawal, Rajesh, Realo, Anu, Rueedi, Rico, Schmidt, Borge, Smith, Albert V., Stergiakouli, Evie, Tanaka, Toshiko, Taylor, Kent, Wedenoja, Juho, Wellmann, Juergen, Westra, Harm-Jan, Willems, Sara M., Zhao, Wei, Amin, Najaf, Bakshi, Andrew, Boyle, Patricia A., Cherney, Samantha, Cox, Simon R., Davies, Gail, Davis, Oliver S. P., Ding, Jun, Direk, Nese, Eibich, Peter, Emeny, Rebecca T., Fatemifar, Ghazaleh, Faul, Jessica D., Ferrucci, Luigi, Forstner, Andreas, Gieger, Christian, Gupta, Richa, Harris, Tamara B., Harris, Juliette M., Holliday, Elizabeth G., Hottenga, Jouke-Jan, De Jager, Philip L., Kaakinen, Marika A., Kajantie, Eero, Karhunen, Ville, Kolcic, Ivana, Kumari, Meena, Launer, Lenore J., Franke, Lude, Li-Gao, Ruifang, Koini, Marisa, Loukola, Anu, Marques-Vidal, Pedro, Montgomery, Grant W., Mosing, Miriam A., Paternoster, Lavinia, Pattie, Alison, Petrovic, Katja E., Pulkki-Raback, Laura, Quaye, Lydia, Raikkonen, Katri, Rudan, Igor, Scott, Rodney J., Smith, Jennifer A., Sutin, Angelina R., Trzaskowski, Maciej, Vinkhuyzen, Anna E., Yu, Lei, Zabaneh, Delilah, Attia, John R., Bennett, David A., Berger, Klaus, Bertram, Lars, Boomsma, Dorret I., Snieder, Harold, Chang, Shun-Chiao, Cucca, Francesco, Deary, Ian J., van Duijn, Cornelia M., Eriksson, Johan G., Bultmann, Ute, de Geus, Eco J. C., Groenen, Patrick J. F., Gudnason, Vilmundur, Hansen, Torben, Hartman, Catharine A., Haworth, Claire M. A., Hayward, Caroline, Heath, Andrew C., Hinds, David A., Hypponen, Elina, Iacono, William G., Jarvelin, Marjo-Riitta, Jockel, Karl-Heinz, Kaprio, Jaakko, Kardia, Sharon L. R., Keltikangas-Jarvinen, Liisa, Kraft, Peter, Kubzansky, Laura D., Lehtimaki, Terho, Magnusson, Patrik K. E., Martin, Nicholas G., Mcgue, Matt, Metspalu, Andres, Mills, Melinda, de Mutsert, Renee, Oldehinkel, Albertine J., Pasterkamp, Gerard, Pedersen, Nancy L., Plomin, Robert, Polasek, Ozren, Power, Christine, Rich, Stephen S., Rosendaal, Frits R., den Ruijter, Hester M., Schlessinger, David, Schmidt, Helena, Svento, Rauli, Schmidt, Reinhold, Alizadeh, Behrooz Z., Sorensen, Thorkild I. A., Spector, Tim D., Steptoe, Andrew, Terracciano, Antonio, Thurik, A. Roy, Timpson, Nicholas J., Tiemeier, Henning, Uitterlinden, Andre G., Vollenweider, Peter, Wagner, Gert G., Weir, David R., Yang, Jian, Conley, Dalton C., Smith, George Davey, Hofman, Albert, Johannesson, Magnus, Laibson, David I., Medland, Sarah E., Meyer, Michelle N., Pickrell, Joseph K., Esko, Tonu, Krueger, Robert F., Beauchamp, Jonathan P., Koellinger, Philipp D., Benjamin, Daniel J., Bartels, Meike and Cesarini, David (2016) Genetic variants associated with subjective well-being, depressive symptoms, and neuroticism identified through genome-wide analyses. Nature Genetics, 48 6: 624-633. doi:10.1038/ng.3552


Author Okbay, Aysu
Baselmans, Bart M. L.
De Neve, Jan-Emmanuel
Turley, Patrick
Nivard, Michel G.
Fontana, Mark Alan
Meddens, S. Fleur W.
Linner, Richard Karlsson
Rietveld, Cornelius A.
Derringer, Jaime
Gratten, Jacob
Lee, James J.
Liu, Jimmy Z.
de Vlaming, Ronald
Ahluwalia, Tarunveer S.
Buchwald, Jadwiga
Cavadino, Alana
Frazier-Wood, Alexis C.
Furlotte, Nicholas A.
Garfield, Victoria
Geisel, Marie Henrike
Gonzalez, Juan R.
Haitjema, Saskia
Karlsson, Robert
van der Laan, Sander W.
Ladwig, Karl-Heinz
Lahti, Jari
van der Lee, Sven J.
Lind, Penelope A.
Liu, Tian
Matteson, Lindsay
Mihailov, Evelin
Miller, Michael B.
Minica, Camelia C.
Nolte, Ilja M.
Mook-Kanamori, Dennis
van der Most, Peter J.
Oldmeadow, Christopher
Qian, Yong
Raitakari, Olli
Rawal, Rajesh
Realo, Anu
Rueedi, Rico
Schmidt, Borge
Smith, Albert V.
Stergiakouli, Evie
Tanaka, Toshiko
Taylor, Kent
Wedenoja, Juho
Wellmann, Juergen
Westra, Harm-Jan
Willems, Sara M.
Zhao, Wei
Amin, Najaf
Bakshi, Andrew
Boyle, Patricia A.
Cherney, Samantha
Cox, Simon R.
Davies, Gail
Davis, Oliver S. P.
Ding, Jun
Direk, Nese
Eibich, Peter
Emeny, Rebecca T.
Fatemifar, Ghazaleh
Faul, Jessica D.
Ferrucci, Luigi
Forstner, Andreas
Gieger, Christian
Gupta, Richa
Harris, Tamara B.
Harris, Juliette M.
Holliday, Elizabeth G.
Hottenga, Jouke-Jan
De Jager, Philip L.
Kaakinen, Marika A.
Kajantie, Eero
Karhunen, Ville
Kolcic, Ivana
Kumari, Meena
Launer, Lenore J.
Franke, Lude
Li-Gao, Ruifang
Koini, Marisa
Loukola, Anu
Marques-Vidal, Pedro
Montgomery, Grant W.
Mosing, Miriam A.
Paternoster, Lavinia
Pattie, Alison
Petrovic, Katja E.
Pulkki-Raback, Laura
Quaye, Lydia
Raikkonen, Katri
Rudan, Igor
Scott, Rodney J.
Smith, Jennifer A.
Sutin, Angelina R.
Trzaskowski, Maciej
Vinkhuyzen, Anna E.
Yu, Lei
Zabaneh, Delilah
Attia, John R.
Bennett, David A.
Berger, Klaus
Bertram, Lars
Boomsma, Dorret I.
Snieder, Harold
Chang, Shun-Chiao
Cucca, Francesco
Deary, Ian J.
van Duijn, Cornelia M.
Eriksson, Johan G.
Bultmann, Ute
de Geus, Eco J. C.
Groenen, Patrick J. F.
Gudnason, Vilmundur
Hansen, Torben
Hartman, Catharine A.
Haworth, Claire M. A.
Hayward, Caroline
Heath, Andrew C.
Hinds, David A.
Hypponen, Elina
Iacono, William G.
Jarvelin, Marjo-Riitta
Jockel, Karl-Heinz
Kaprio, Jaakko
Kardia, Sharon L. R.
Keltikangas-Jarvinen, Liisa
Kraft, Peter
Kubzansky, Laura D.
Lehtimaki, Terho
Magnusson, Patrik K. E.
Martin, Nicholas G.
Mcgue, Matt
Metspalu, Andres
Mills, Melinda
de Mutsert, Renee
Oldehinkel, Albertine J.
Pasterkamp, Gerard
Pedersen, Nancy L.
Plomin, Robert
Polasek, Ozren
Power, Christine
Rich, Stephen S.
Rosendaal, Frits R.
den Ruijter, Hester M.
Schlessinger, David
Schmidt, Helena
Svento, Rauli
Schmidt, Reinhold
Alizadeh, Behrooz Z.
Sorensen, Thorkild I. A.
Spector, Tim D.
Steptoe, Andrew
Terracciano, Antonio
Thurik, A. Roy
Timpson, Nicholas J.
Tiemeier, Henning
Uitterlinden, Andre G.
Vollenweider, Peter
Wagner, Gert G.
Weir, David R.
Yang, Jian
Conley, Dalton C.
Smith, George Davey
Hofman, Albert
Johannesson, Magnus
Laibson, David I.
Medland, Sarah E.
Meyer, Michelle N.
Pickrell, Joseph K.
Esko, Tonu
Krueger, Robert F.
Beauchamp, Jonathan P.
Koellinger, Philipp D.
Benjamin, Daniel J.
Bartels, Meike
Cesarini, David
Title Genetic variants associated with subjective well-being, depressive symptoms, and neuroticism identified through genome-wide analyses
Journal name Nature Genetics   Check publisher's open access policy
ISSN 1546-1718
1061-4036
Publication date 2016-06-01
Year available 2016
Sub-type Article (original research)
DOI 10.1038/ng.3552
Open Access Status Not yet assessed
Volume 48
Issue 6
Start page 624
End page 633
Total pages 10
Place of publication New York, NY, United States
Publisher Nature Publishing Group
Language eng
Subject 1311 Genetics
Abstract Very few genetic variants have been associated with depression and neuroticism, likely because of limitations on sample size in previous studies. Subjective well-being, a phenotype that is genetically correlated with both of these traits, has not yet been studied with genome-wide data. We conducted genome-wide association studies of three phenotypes: subjective well-being (n = 298,420), depressive symptoms (n = 161,460), and neuroticism (n = 170,911). We identify 3 variants associated with subjective well-being, 2 variants associated with depressive symptoms, and 11 variants associated with neuroticism, including 2 inversion polymorphisms. The two loci associated with depressive symptoms replicate in an independent depression sample. Joint analyses that exploit the high genetic correlations between the phenotypes (|ρ^| ≈ 0.8) strengthen the overall credibility of the findings and allow us to identify additional variants. Across our phenotypes, loci regulating expression in central nervous system and adrenal or pancreas tissues are strongly enriched for association.
Formatted abstract
Very few genetic variants have been associated with depression and neuroticism, likely because of limitations on sample size in previous studies. Subjective well-being, a phenotype that is genetically correlated with both of these traits, has not yet been studied with genome-wide data. We conducted genome-wide association studies of three phenotypes: subjective well-being (n = 298,420), depressive symptoms (n = 161,460), and neuroticism (n = 170,911). We identify 3 variants associated with subjective well-being, 2 variants associated with depressive symptoms, and 11 variants associated with neuroticism, including 2 inversion polymorphisms. The two loci associated with depressive symptoms replicate in an independent depression sample. Joint analyses that exploit the high genetic correlations between the phenotypes ( |p|≈ 0.8) strengthen the overall credibility of the findings and allow us to identify additional variants. Across our phenotypes, loci regulating expression in central nervous system and adrenal or pancreas tissues are strongly enriched for association.
Keyword Genetics & Heredity
Genetics & Heredity
Q-Index Code C1
Q-Index Status Provisional Code
Grant ID R01 DA036216
RF1 AG015819
MC_UU_12013/3
R01 AG017917
MR/J012165/1
R03 AG051960
UL1 TR000124
P30 DK063491
MC_PC_15018
P30 AG010161
MC_UU_12013/1
MC_PC_U127561128
P01 AG005842
R37 DA005147
P30 AG012810
R01 AG042568
T32 AG000186
647648
Institutional Status UQ

Document type: Journal Article
Sub-type: Article (original research)
Collections: HERDC Pre-Audit
Queensland Brain Institute Publications
UQ Diamantina Institute Publications
 
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