Perfusion measurement in brain gliomas with intravoxel incoherent motion MRI

Federau, C., Meuli, R., O'Brien, K., Maeder, P. and Hagmann, P. (2014) Perfusion measurement in brain gliomas with intravoxel incoherent motion MRI. American Journal of Neuroradiology, 35 2: 256-262. doi:10.3174/ajnr.A3686


Author Federau, C.
Meuli, R.
O'Brien, K.
Maeder, P.
Hagmann, P.
Title Perfusion measurement in brain gliomas with intravoxel incoherent motion MRI
Journal name American Journal of Neuroradiology   Check publisher's open access policy
ISSN 0195-6108
1936-959X
Publication date 2014-01-01
Sub-type Article (original research)
DOI 10.3174/ajnr.A3686
Open Access Status DOI
Volume 35
Issue 2
Start page 256
End page 262
Total pages 7
Place of publication Oak Brook, IL United States
Publisher American Society of Neuroradiology
Language eng
Formatted abstract
BACKGROUND AND PURPOSE: Intravoxel incoherent motion MRI has been proposed as an alternative method to measure brain perfusion. Our aim was to evaluate the utility of intravoxel incoherent motion perfusion parameters (the perfusion fraction, the pseudodiffusion coefficient, and the flow-related parameter) to differentiate high- and low-grade brain gliomas.

MATERIALS AND METHODS: The intravoxel incoherent motion perfusion parameters were assessed in 21 brain gliomas (16 high-grade, 5 low-grade). Images were acquired by using a Stejskal-Tanner diffusion pulse sequence, with 16 values of b (0–900 s/mm2) in 3 orthogonal directions on 3T systems equipped with 32 multichannel receiver head coils. The intravoxel incoherent motion perfusion parameters were derived by fitting the intravoxel incoherent motion biexponential model. Regions of interest were drawn in regions of maximum intravoxel incoherent motion perfusion fraction and contralateral control regions. Statistical significance was assessed by using the Student t test. In addition, regions of interest were drawn around all whole tumors and were evaluated with the help of histograms.

RESULTS: In the regions of maximum perfusion fraction, perfusion fraction was significantly higher in the high-grade group (0.127 ± 0.031) than in the low-grade group (0.084 ± 0.016, P < .001) and in the contralateral control region (0.061 ± 0.011, P < .001). No statistically significant difference was observed for the pseudodiffusion coefficient. The perfusion fraction correlated moderately with dynamic susceptibility contrast relative CBV (r = 0.59). The histograms of the perfusion fraction showed a “heavy-tailed” distribution for high-grade but not low-grade gliomas.

CONCLUSIONS: The intravoxel incoherent motion perfusion fraction is helpful for differentiating high- from low-grade brain gliomas.
Q-Index Code C1
Q-Index Status Provisional Code
Institutional Status Non-UQ

Document type: Journal Article
Sub-type: Article (original research)
Collection: Centre for Advanced Imaging Publications
 
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