The relationship between vitamin D status and allergic diseases in New Zealand preschool children

Cairncross, Carolyn, Grant, Cameron, Stonehouse, Welma, Conlon, Cath, McDonald, Barry, Houghton, Lisa, Eyles, Darryl, Camargo, Carlos A., Coad, Jane and von Hurst, Pamela (2016) The relationship between vitamin D status and allergic diseases in New Zealand preschool children. Nutrients, 8 6: . doi:10.3390/nu8060326


Author Cairncross, Carolyn
Grant, Cameron
Stonehouse, Welma
Conlon, Cath
McDonald, Barry
Houghton, Lisa
Eyles, Darryl
Camargo, Carlos A.
Coad, Jane
von Hurst, Pamela
Title The relationship between vitamin D status and allergic diseases in New Zealand preschool children
Journal name Nutrients   Check publisher's open access policy
ISSN 2072-6643
Publication date 2016-06-01
Sub-type Article (original research)
DOI 10.3390/nu8060326
Open Access Status DOI
Volume 8
Issue 6
Total pages 10
Place of publication Basel, Switzerland
Publisher MDPI
Language eng
Formatted abstract
Recent research on vitamin D in young children has expanded from bone development to exploring immunomodulatory effects. Our aim was to investigate the relationship of vitamin D status and allergic diseases in preschool-aged children in New Zealand. Dried capillary blood spots were collected from 1329 children during late-winter to early-spring for 25(OH)D measurement by LC-MS/MS. Caregivers completed a questionnaire about their child’s recent medical history. Analysis was by multivariable logistic regression. Mean 25(OH)D concentration was 52(SD19) nmol/L, with 7% of children <25 nmol/L and 49% <50 nmol/L. Children with 25(OH)D concentrations ≥75 nmol/L (n = 29) had a two-fold increased risk for parent-report of doctor-diagnosed food allergy compared to children with 25(OH)D 50–74.9 nmol/L (OR = 2.21, 1.33–3.68, p = 0.002). No associations were present between 25(OH)D concentration and presence of parent-reported eczema, allergic rhinoconjunctivitis or atopic asthma. Vitamin D deficiency was not associated with several allergic diseases in these New Zealand preschool children. In contrast, high 25(OH)D concentrations were associated with a two-fold increased risk of parental-report food allergy. This increase supports further research into the association between vitamin D status and allergic disease in preschool children.
Keyword Allergic disease
Children
New Zealand
Vitamin D
Q-Index Code C1
Q-Index Status Provisional Code
Institutional Status UQ

Document type: Journal Article
Sub-type: Article (original research)
Collections: HERDC Pre-Audit
Queensland Brain Institute Publications
 
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