Decreased severity of ethanol withdrawal behaviors in kainic acid-treated rats

Matsumoto I., Davidson M., Otsuki M. and Wilce P.A. (1996) Decreased severity of ethanol withdrawal behaviors in kainic acid-treated rats. Pharmacology Biochemistry and Behavior, 55 3: 371-378. doi:10.1016/S0091-3057(96)00106-2


Author Matsumoto I.
Davidson M.
Otsuki M.
Wilce P.A.
Title Decreased severity of ethanol withdrawal behaviors in kainic acid-treated rats
Journal name Pharmacology Biochemistry and Behavior   Check publisher's open access policy
ISSN 0091-3057
Publication date 1996-01-01
Sub-type Article (original research)
DOI 10.1016/S0091-3057(96)00106-2
Open Access Status Not yet assessed
Volume 55
Issue 3
Start page 371
End page 378
Total pages 8
Language eng
Subject 1303 Specialist Studies in Education
2802 Behavioral Neuroscience
3004 Pharmacology
Abstract The involvement of kainate (KA)-sensitive regions in ethanol withdrawal behaviors was investigated in male Wistar rats given three intraperitoneal (IP) injections of KA (12 mg/kg) or saline each followed by recovery at 4°C for 5 h and room temperature for 3 days and a final KA or saline injection at room temperature. Some animals received MK-801 (1 mg/kg, IP) 30 min after each injection and one group received saline only. The saline/saline, saline/MK-801, and KA/MK-801 groups displayed typical ethanol withdrawal behaviors 8-12 h after ethanol withdrawal. These behaviors were attenuated in the KA/saline group. Audiogenic seizures could be induced in all treatment groups 12 h after withdrawal. There was severe neuronal degeneration in the hippocampal CA region and the piriform cortex of the KA-saline-treated animals that was reduced by MK-801 treatment. The inferior colliculus remained intact. These results suggest that the N-methyl-D-aspartate receptor mediates KA-induced damage in limbic structures and that these regions may play an important role in typical, but not audiogenically induced ethanol withdrawal behaviors.
Keyword Ethanol withdrawal
Hippocampus
Kainic acid
N-methyl-D-aspartate
Piriform cortex
Seizure
Q-Index Code C1
Q-Index Status Provisional Code
Institutional Status Unknown

Document type: Journal Article
Sub-type: Article (original research)
Collection: Scopus Import - Archived
 
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