Effects of prolactin on steroid production by human luteal cells in vitro

Tan G.J.S. and Biggs J.S.G. (1983) Effects of prolactin on steroid production by human luteal cells in vitro. Journal of Endocrinology, 96 3: 499-503. doi:10.1677/joe.0.0960499


Author Tan G.J.S.
Biggs J.S.G.
Title Effects of prolactin on steroid production by human luteal cells in vitro
Journal name Journal of Endocrinology   Check publisher's open access policy
ISSN 0022-0795
Publication date 1983-01-01
Sub-type Article (original research)
DOI 10.1677/joe.0.0960499
Open Access Status Not yet assessed
Volume 96
Issue 3
Start page 499
End page 503
Total pages 5
Language eng
Subject 1310 Endocrinology
Abstract The effects of prolactin on steroidogenesis were studied in dispersed luteal cells prepared from human corpora lutea of the menstrual cycle. Prolactin, at concentrations of 0.1-1000 ng/ml, had no effect on progesterone production by luteal cells during short-term incubation (3 h). However, in two out of five corpora lutea, higher concentrations of prolactin (100 and 1000 ng/ml) significantly reduced the oestradiol-17β production induced by human chorionic gonadotrophin (hCG; 10 i.u./ml); lower doses of prolactin had little effect. In the remaining corpora lutea, prolactin failed to affect either basal or hCG-induced poduction of oestradiol-17β. These results are discussed in relation to the mechanism by which prolactin influences human ovarian function.
Q-Index Code C1
Q-Index Status Provisional Code
Institutional Status Unknown

Document type: Journal Article
Sub-type: Article (original research)
Collection: Scopus Import - Archived
 
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Created: Tue, 14 Jun 2016, 16:56:29 EST by System User