Mechanisms of myelin basic protein and proteolipid protein targeting in oligodendrocytes (review)

Kalwy S.A. and Smith R. (1994) Mechanisms of myelin basic protein and proteolipid protein targeting in oligodendrocytes (review). Molecular Membrane Biology, 11 2: 67-78. doi:10.3109/09687689409162223


Author Kalwy S.A.
Smith R.
Title Mechanisms of myelin basic protein and proteolipid protein targeting in oligodendrocytes (review)
Journal name Molecular Membrane Biology   Check publisher's open access policy
ISSN 0968-7688
Publication date 1994-01-01
Sub-type Article (original research)
DOI 10.3109/09687689409162223
Volume 11
Issue 2
Start page 67
End page 78
Total pages 12
Publisher Informa Healthcare
Subject 1307 Cell Biology
1312 Molecular Biology
Abstract Summary The segregation of proteins to specific cellular membranes is recognized as a common phenomenon. In oligodendrocytes of the central nervous system, localization of certain proteins to select regions of the plasma membrane gives rise to the myelin membrane. Whilst the fundamental structure and composition of myelin is well understood, less is known of the mechanisms by which the constituent proteins are specifically recruited to those regions of plasma membrane that are forming myelin. The two principal proteins of myelin, the myelin basic protein and proteolipid protein, differ greatly in character and sites of synthesis. The message for myelin basic protein is selectively translocated to the ends of the cell processes, where it is translated on free ribosomes and is incorporated directly into the membrane. Proteolipid protein synthesized at the rough endoplasmic reticulum, processed through the Golgi apparatus, and presumably transported via vesicles to the myelin membrane. This review examines the mechanisms by which these two proteins are targeted to the myelin membrane.
Keyword MRNA transport
Myelin basic protein
Oligodendrocytes
Protein sorting
Proteolipid protein
Q-Index Code C1
Q-Index Status Provisional Code
Institutional Status Unknown

Document type: Journal Article
Sub-type: Article (original research)
Collection: Scopus Import - Archived
 
Versions
Version Filter Type
Citation counts: Scopus Citation Count Cited 26 times in Scopus Article | Citations
Google Scholar Search Google Scholar
Created: Tue, 14 Jun 2016, 16:13:55 EST by System User