Simultaneous plasma carbamazepine and carbamazepine-epoxide concentrations in pharmacokinetic and bioavailability studies

Hooper W.D., King A.R., Patterson M., Dickinson R.G. and Eadie M.J. (1985) Simultaneous plasma carbamazepine and carbamazepine-epoxide concentrations in pharmacokinetic and bioavailability studies. Therapeutic Drug Monitoring, 7 1: 36-40.

Author Hooper W.D.
King A.R.
Patterson M.
Dickinson R.G.
Eadie M.J.
Title Simultaneous plasma carbamazepine and carbamazepine-epoxide concentrations in pharmacokinetic and bioavailability studies
Journal name Therapeutic Drug Monitoring   Check publisher's open access policy
ISSN 1536-3694
Publication date 1985-01-01
Sub-type Article (original research)
Volume 7
Issue 1
Start page 36
End page 40
Total pages 5
Subject 2736 Pharmacology (medical)
3004 Pharmacology
3005 Toxicology
2307 Health, Toxicology and Mutagenesis
1303 Specialist Studies in Education
1300 Biochemistry, Genetics and Molecular Biology
2739 Public Health, Environmental and Occupational Health
Abstract A comparative bioavailability study of carbamazepine (CBZ) in tablets and a syrup preparation was carried out in six volunteers, using a crossover design. Plasma and saliva samples were collected at appropriate times, and the plasma specimens were analyzed by high performance liquid chromatography for concentrations of CBZ and its epoxide metabolite (CBZ-EP). Analysis of the data showed that the preparations were equally bioavailable, although absorption was faster from the syrup and gave higher maximum plasma levels of CBZ. In other respects the preparations were pharmacokinetically equivalent. Analysis of simultaneous plasma CBZ and CBZ-EP concentration-time data by iterative curve fitting to a one-compartment linear model permitted the calculation of elimination kinetic parameters of the CBZ-EP; the mean elimination half-life was 6.9 ± 2.7 h. Failure of the salivary CBZ concentrations soon after drug intake to correlate with simultaneous plasma CBZ levels rendered the salivary data useless for bioavailability comparison, but prompted a further study of salivary CBZ levels.
Keyword Bioavailability
Carbamazepine
Carbamazepine-epoxide
Pharmacokinetics
Q-Index Code C1
Q-Index Status Provisional Code
Institutional Status Unknown

Document type: Journal Article
Sub-type: Article (original research)
Collection: Scopus Import - Archived
 
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Created: Tue, 14 Jun 2016, 15:53:10 EST by System User