The basis for aspirin dosage in stroke prevention.

Brandon R.A. and Eadie M.J. (1987) The basis for aspirin dosage in stroke prevention.. Clinical and experimental neurology, 23 47-54.

Author Brandon R.A.
Eadie M.J.
Title The basis for aspirin dosage in stroke prevention.
Journal name Clinical and experimental neurology   Check publisher's open access policy
ISSN 0196-6383
Publication date 1987-01-01
Sub-type Article (original research)
Open Access Status Not yet assessed
Volume 23
Start page 47
End page 54
Total pages 8
Language eng
Subject 2700 Medicine
Abstract Many strokes are thought to develop as a consequence of platelet aggregation on areas of arterial endothelial damage, with subsequent embolism or thrombus formation. Aspirin prevents platelet adhesion and aggregation by inhibiting the formation of thromboxane A2 by platelets. This suggests that aspirin could be used to prevent stroke. However aspirin also inhibits endothelial formation of the anti-aggregatory substance prostacyclin, though probably only in a slightly higher dose than that just capable of inhibiting platelet aggregation. Consequently, too high an aspirin dose may defeat its purpose. The effect of aspirin on platelets lasts for as long as they survive, whereas the effects of aspirin on endothelium are shorter. Theoretical considerations suggest that aspirin, given in brief pulses just to reach platelet inhibitory concentrations in plasma, and administered at the maximum interval that will maintain inhibition of platelet aggregation, should offer the most favourable balance between altered platelet and altered endothelial function from the viewpoint of stroke prevention. Data are presented showing that rapid rather than slow or delayed release aspirin preparations are necessary to achieve suitable plasma aspirin concentration-time profiles in humans, and that a peak plasma aspirin concentration of around 1.2 mg/L is necessary in vivo to inhibit aggregability of previously untreated platelets.
Q-Index Code C1
Q-Index Status Provisional Code
Institutional Status Unknown

Document type: Journal Article
Sub-type: Article (original research)
Collection: Scopus Import - Archived
 
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Created: Tue, 14 Jun 2016, 15:32:19 EST by System User