The effects of immune depression on chemical carcinogenesis in the rat: III. cyclophosphamide

Bolton P.M. (1973) The effects of immune depression on chemical carcinogenesis in the rat: III. cyclophosphamide. Oncology (Switzerland), 27 6: 525-532. doi:10.1159/000224762


Author Bolton P.M.
Title The effects of immune depression on chemical carcinogenesis in the rat: III. cyclophosphamide
Journal name Oncology (Switzerland)   Check publisher's open access policy
ISSN 1423-0232
Publication date 1973-01-01
Sub-type Article (original research)
DOI 10.1159/000224762
Volume 27
Issue 6
Start page 525
End page 532
Total pages 8
Subject 1306 Cancer Research
2730 Oncology
Abstract The effect of the immunosuppressive drug cyclophosphamide upon the incidence and growth characteristics of rat mammary tumour induced by 7,12-dimethyl benz- (α)-anthracene has been investigated. Where cyclophosphamide was administered six days before or concurrently with the carcinogen, there was a decreased incidence and an increased latency of induced tumours. However, when the cyclophosphamide was commenced six days after the first dose of carcinogen there was an increased incidence of tumours and a decreased latency. While the exact explanation of this phenomenon is uncertain, it may be that cyclophosphamide exerts a maximal cytotoxic effect at the time of tumour induction or very early in its growth; when given after the tumour is established, the immunosuppressive effect on the host may outweigh any direct cytotoxic effect upon the tumour in this system.
Keyword 7,12-Dimethyl benz-(α)-anthracene
Carcinogenesis
Cyclophosphamide
Immunosuppression
Rat mammary tumours
Q-Index Code C1
Q-Index Status Provisional Code
Institutional Status Unknown

Document type: Journal Article
Sub-type: Article (original research)
Collection: Scopus Import - Archived
 
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Created: Tue, 14 Jun 2016, 15:30:54 EST by System User