Suppression of monocyte and neutrophil function by recombinant IL-2

Smith S.E., Smith S.E., Warren G.D., Thong Y.-H. and Mccormack J.G. (1993) Suppression of monocyte and neutrophil function by recombinant IL-2. Mediators of Inflammation, 2 1: 59-65. doi:10.1155/S0962935193000080

Author Smith S.E.
Smith S.E.
Warren G.D.
Thong Y.-H.
Mccormack J.G.
Title Suppression of monocyte and neutrophil function by recombinant IL-2
Journal name Mediators of Inflammation   Check publisher's open access policy
ISSN 1466-1861
Publication date 1993-01-01
Sub-type Article (original research)
DOI 10.1155/S0962935193000080
Open Access Status DOI
Volume 2
Issue 1
Start page 59
End page 65
Total pages 7
Language eng
Subject 2403 Immunology
1307 Cell Biology
Abstract Little is known about the influence of IL-2 on phagocytes. We now describe the effects of human recombinant IL-2 on human neutrophil and monocyte functions related to mobility, phagocytosis, glucose uptake, respiration and degranulation. Neutrophil adherence and hexose monophosphate shunt activities were both suppressed after incubation with IL-2. IL-2 had no effect on neutrophil migration, phagocytosis, deoxyglucose uptake or degranulation. Monocytes demonstrated a greater sensitivity to IL-2 with suppression of monocyte adherence, random and stimulated migration, glucose uptake and hexose monophosphate shunt activity, even after addition of phorbol myristate acetate. Monocyte phagocytosis and degranulation were not affected. All of the effects observed were dose-dependent within a biologically active range for IL-2. These studies suggest that IL-2 may have an important down-regulatory role across a broad range of monocyte functions including movement, deoxyglucose uptake and respiration. However, its role in regulation of neutrophil function is limited to adherence and respiration. IL-2 may be a more versatile cytokine than has previously been appreciated.
Keyword Cell function
Immune regulation
Phagocyte suppression
Q-Index Code C1
Q-Index Status Provisional Code
Institutional Status Unknown

Document type: Journal Article
Sub-type: Article (original research)
Collection: Scopus Import - Archived
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Citation counts: Scopus Citation Count Cited 2 times in Scopus Article | Citations
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Created: Tue, 14 Jun 2016, 15:03:12 EST by System User