Identification of the coupling between skeletal muscle store-operated Ca2+ entry and the inositol trisphosphate receptor

Launikonis, Bradley S., Barnes, Melissa and Stephenson, D. George (2003) Identification of the coupling between skeletal muscle store-operated Ca2+ entry and the inositol trisphosphate receptor. Proceedings of The National Academy of Sciences of The United States of America, 100 5: 2941-2944. doi:10.1073/pnas.0536227100


Author Launikonis, Bradley S.
Barnes, Melissa
Stephenson, D. George
Title Identification of the coupling between skeletal muscle store-operated Ca2+ entry and the inositol trisphosphate receptor
Journal name Proceedings of The National Academy of Sciences of The United States of America   Check publisher's open access policy
ISSN 0027-8424
1091-6490
Publication date 2003-03-04
Sub-type Article (original research)
DOI 10.1073/pnas.0536227100
Volume 100
Issue 5
Start page 2941
End page 2944
Total pages 4
Place of publication Washington D.C
Publisher National Academy of Sciences of the U.S.
Language eng
Abstract Examination of store-operated Ca2+ entry (SOC) in single, mechanically skinned skeletal muscle cells by confocal microscopy shows that the inositol 1,4,5-trisphosphate (IP3) receptor acts as a sarcoplasmic reticulum [Ca2+] sensor and mediates SOC by physical coupling without playing a key role in Ca2+ release from internal stores, as is the case with various cell types in which SOC was investigated previously. The results have broad implications for understanding the mechanism of SOC that is essential for cell function in general and muscle function in particular. Moreover, the study ascribes an important role to the IN receptors in skeletal muscle, the role of which with respect to Ca2+ homeostasis was ill defined until now.
Keyword Physiology
Capacitative Calcium-entry
Sarcoplasmic-reticulum
1,4,5-trisphosphate Receptor
Tubular System
Toad
Channels
Fibers
Rat
Release
Localization
Multidisciplinary Sciences
Q-Index Code C1
Q-Index Status Provisional Code
Institutional Status Unknown

Document type: Journal Article
Sub-type: Article (original research)
Collections: Excellence in Research Australia (ERA) - Collection
School of Biomedical Sciences Publications
 
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Created: Mon, 13 Aug 2007, 23:26:09 EST