Carcinogenesis by Carbamic Acid Esters and Their Binding to DNA

Pound A.W. and Lawson T.A. (1976) Carcinogenesis by Carbamic Acid Esters and Their Binding to DNA. Cancer Research, 36 3: 1101-1107.

Author Pound A.W.
Lawson T.A.
Title Carcinogenesis by Carbamic Acid Esters and Their Binding to DNA
Journal name Cancer Research   Check publisher's open access policy
ISSN 1538-7445
Publication date 1976-01-01
Sub-type Article (original research)
Volume 36
Issue 3
Start page 1101
End page 1107
Total pages 7
Subject 1306 Cancer Research
2730 Oncology
Abstract The tumor-initiating potency of three simple alkyl carbamates and mono-N-substituted ethyl carbamates was examined in Hall strain mice. The binding of, 4 C-labeled carbamates to DNA was measured in Crackenbush mice. Ethyl carbamate was the most potent carcinogen for the epidermis, liver, and lung, followed by its N-alkyl derivatives. Methyl carbamate was without effect but n-propyl and n-butyl were possible carcinogens. The ethyl esters bound to a greater extent to DNA in liver and skin than the methyl, n-propyl, and n-butyl esters and only this binding persisted. A preliminary application of croton oil increased the yield of skin tumors but not of liver or lung tumors. It also increased the binding of the alkyl carbamates to DNA in skin, the increase being greatest with ethyl carbamate. The binding persisted longer in treated than in non-croton oil-treated mice.
Q-Index Code C1
Q-Index Status Provisional Code
Institutional Status Unknown

Document type: Journal Article
Sub-type: Article (original research)
Collection: Scopus Import - Archived
Version Filter Type
Citation counts: Scopus Citation Count Cited 7 times in Scopus Article | Citations
Google Scholar Search Google Scholar
Created: Tue, 14 Jun 2016, 14:16:38 EST by System User